Systems biology dissection of PTSD and MDD across brain regions, cell types, and blood  

作　　者：Nikolaos P Daskalakis 

机构地区：[1]不详

出　　处：《四川生理科学杂志》2024年第5期1111-1111,共1页Sichuan Journal of Physiological Sciences

摘　　要：The molecular pathology of stress-related disorders remains elusive.Our brain multiregion,multiomic study of posttraumatic stress disorder(PTSD)and major depressive disorder(MDD)included the central nucleus of the amygdala,hippocampal dentate gyrus,and medial prefrontal cortex(mPFC).Genes and exons within the mPFC carried most disease signals replicated across two independent cohorts.Pathways pointed to immune function,neuronal and synaptic regulation,and stress hormones.Multiomic factor and gene network analyses provided the underlying genomic structure.

关 键 词：structure. CORTEX MEDIAL 

分 类 号：R749.4[医药卫生—神经病学与精神病学]