细胞焦亡在脑缺血再灌注损伤中的研究进展  

Research progress of pyrodeath in cerebral ischemia-reperfusion injury

作　　者：张玉慧 潘彦瑾 吴启光 白泽宇 王勇 Zhang Yu-hui;Pan Yan-jin;Wu Qi-guang;Bai Ze-yu;Wang Yong(Guangxi Key Laboratory of Tumor Immunity and Microenvironment Regulation,Guilin 541199,Guangxi,China;Department of Physiology,Guilin Medical College,Guilin 541199,Guangxi,China)

机构地区：[1]广西肿瘤免疫与微环境调控重点实验室,广西桂林541199 [2]桂林医学院生理学教研室,广西桂林541199

出　　处：《四川生理科学杂志》2024年第5期1168-1171,共4页Sichuan Journal of Physiological Sciences

基　　金：国家自然科学基金地区科学基金项目(编号:82260711)。

摘　　要：细胞焦亡(Proptosis)是近年来发现的一种程序性细胞死亡形式,主要依靠炎症小体激活部分Caspase家族蛋白(Caspase-1/4/5/11),切割其下游的Gasdermin-D(GSDMD)蛋白后,定位到细胞膜上形成孔洞,最终导致细胞膜破裂,并释放出细胞内容物及炎性因子等。目前研究表明,细胞焦亡参与了脑缺血再灌注的损伤过程。本文着重探讨细胞焦亡在脑缺血再灌注损伤中的机制及相关药物治疗进展,以期为缺血性脑卒中的防治提供一定理论依据。Proptosis is a form of programmed cell death discovered in recent years.It mainly relies on inflammatosomes to activate part of Caspase family proteins(Caspase-1/4/5/11).After cutting the downstream Gasdermin-D(GSDMD)protein,proptosis is localized to the cell membrane to form pores.Eventually,the cell membrane breaks down and cell contents and inflammatory factors are released.Current studies have shown that pyrodeath is involved in the injury process of cerebral ischemia-reperfusion.This article focuses on the mechanism of pyrodeath in cerebral ischemia-reperfusion injury and the progress of related drug treatment,in order to provide a theoretical basis for the prevention and treatment of ischemic stroke.

关 键 词：脑缺血再灌注损伤 细胞焦亡 NLRP3 CASPASE-1 GSDMD 

分 类 号：R743.31[医药卫生—神经病学与精神病学]