基于老药新用二甲双胍抑制卵巢癌机制的研究进展  

Research progress on the mechanism of inhibition of ovarian cancer with metformin based on old drugs and new use

作　　者：周宇恒 李玥潼 王越 丁琳 ZHOU Yuheng;LI Yuetong;WANG Yue;DING Lin(Department of Clinical Medicine,Nantong University Xinglin College,Jiangsu 226019;International High School,Rugao International Academy;Medical Department,Nantong University Xinglin College)

机构地区：[1]南通大学杏林学院临床医学系,江苏226019 [2]如皋市龙游湖外国语学校国际高中部 [3]南通大学杏林学院医学部

出　　处：《南通大学学报（医学版）》2024年第2期172-176,共5页Journal of Nantong University(Medical sciences)

基　　金：国家自然科学基金资助项目(82072536);江苏省自然科学基金资助项目(BK20191182)。

摘　　要：卵巢癌在妇科恶性肿瘤中致死率最高,因卵巢癌初期临床症状不明显,绝大部分患者就诊时已是疾病发展的终末期,常伴有腹、盆腔积液和癌细胞转移等,同时卵巢癌细胞易对以铂类为基础的化疗药产生耐药性,且对复发耐药患者目前没有统一的治疗方案,耐药细胞对卡铂、紫杉醇、二线化疗药(多西他赛、多柔比星脂质体)等没有明显反应,导致卵巢癌的致死率一直居高不下。为了提高卵巢癌的治疗效果,延缓复发,有必要研究新的治疗方法,与研究新药相比,挖掘传统非肿瘤药物的抗肿瘤作用,可能是一种安全且高效的研究思路。其中二甲双胍是“老药新用”的一个典型代表,二甲双胍属胍的衍生物,主要适应证为2型糖尿病。近来,随着人们对二甲双胍的作用机制以及生物活性的深入研究,发现它有潜在的抗癌作用。二甲双胍对乳腺癌、卵巢癌、胰腺癌、肺癌等恶性肿瘤均有抑制作用,其主要机制有AMP活化蛋白激酶通路、改善铂类耐药、癌细胞转移抑制、改变免疫细胞功能、敏感性等。本文就二甲双胍抑制卵巢癌的具体机制进行综述。Among gynecological malignant tumors,ovarian cancer has the highest fatality rate,because the initial clinical symptoms of ovarian cancer are not obvious,most patients are in the terminal stage of disease development at the time of presentation,often accompanied by abdominal and pelvic effusion and metastasis of cancer cells,etc.,while ovarian cancer cells are prone to resistance to platinum-based chemotherapy drugs,and relapsed resistant patients currently have no unified treatment plan,drug-resistant cancer cells to carboplatin,paclitaxel,second-line chemotherapy drugs(docetaxel,Doxorubicin liposomes)and so on have no obvious reaction,so the fatality rate of ovarian cancer has remained high.In order to improve the treatment effect of ovarian cancer and delay the recurrence,it is necessary to research new treatment methods.Compared with the study of new drugs,mining the anti-tumor effect of traditional non-tumor drugs may be a safe and efficient research idea.Among them,metformin is a typical representative of"old drugs and new use",a derivative of metformin,the main indication is type 2 diabetes.Recently,with the in-depth study of the mechanism of action and biological activity of metformin,it has been found that it has the potential for anti-cancer effects.Metformin has inhibitory effects on breast cancer,ovarian cancer,pancreatic cancer,lung cancer and other malignant tumors.Its main mechanisms include AMP activated protein kinase pathway,improvement of platinum resistance,inhibition of cancer cell metastasis,change of immune cell function,sensitivity,etc.This article reviews the specific mechanism of metformin in inhibiting ovarian cancer.

关 键 词：卵巢癌 二甲双胍 糖尿病 作用机制 化学治疗 耐药 

分 类 号：R737.31[医药卫生—肿瘤]