SCAMP2和SCAMP3在膀胱癌中的表达及意义  

Expression and significance of secretory carrier membrane protein 2 and secretory carrier membrane protein 3 in bladder cancer

作　　者：曲婷婷[1] 赵树超[1] 闫伟华[1] 张翔雁 贾长新[2] QU Tingting;ZHAO Shuchao;YAN Weihua;ZHANG Xiangyan;JIA Changxin(Department of Pathology,The Affiliated Hospital of Qingdao University,Qingdao 266000,China)

机构地区：[1]青岛大学附属医院,病理科,山东青岛266000 [2]青岛大学附属医院麻醉科,山东青岛266000

出　　处：《青岛大学学报（医学版）》2024年第2期222-226,共5页Journal of Qingdao University(Medical Sciences)

基　　金：山东省医药卫生科技发展计划项目(20210411-0960);青岛大学附属医院青年科研基金(QDFYQN2023227)。

摘　　要：目的探讨分泌载体相关膜蛋白2和3(SCAMP2和SCAMP3)在膀胱癌(BC)中的表达及其意义。方法应用免疫组织化学法检测181例BC及相应癌旁组织中SCAMP2和SCAMP3的表达水平。结果与相应癌旁组织相比较,SCAMP2和SCAMP3在BC组织中的表达水平显著升高(χ^(2)=41.242、110.576,P<0.001)。SCAMP2高表达与饮酒史和癌症家族史有关(χ^(2)=4.784、3.904,P<0.05)。SCAMP3高表达与浸润性BC和癌症家族史有关(χ^(2)=6.893、7.411,P<0.05)。预后分析显示,SCAMP2和SCAMP3表达与BC病人预后没有相关性。结论SCAMP2和SCAMP3在BC组织中的高表达可能与BC的发生和进展密切相关,可能可以作为BC治疗的潜在靶点。Objective To investigate the expression and significance of secretory carrier membrane protein 2(SCAMP2)and secretory carrier membrane protein 3(SCAMP3)in bladder cancer(BC).Methods Immunohistochemistry was used to measure the expression levels of SCAMP2 and SCAMP3 in 181 BC tissue samples and the corresponding adjacent tissue samples.[WTHX]ResultsThe expression levels of SCAMP2 and SCAMP3 in BC tissue samples were significantly higher than those in adjacent tissue samples(χ^(2)=41.242,110.576;P<0.001).The high expression of SCAMP2 was significantly associated with alcohol intake and a family history of cancer(χ^(2)=4.784,3.904;P<0.05),while high SCAMP3 expression was significantly associated with invasive BC and a family history of cancer(χ^(2)=6.893,7.411;P<0.05).The prognosis analysis showed that the expression of SCAMP2 and SCAMP3 was not associated with the prognosis of patients.ConclusionThe high expression of SCAMP2 and SCAMP3 in BC tissue may be closely associated with the development and progression of BC,and therefore,they can be used as potential therapeutic targets for BC.

关 键 词：膀胱肿瘤 载体蛋白质类 膜蛋白质类 疾病特征 预后 免疫组织化学 

分 类 号：R737.14[医药卫生—肿瘤]