衰老与恶性肿瘤——被忽视的免疫衰老  

Aging and malignant tumors--the neglected immunosenescence

作　　者：张开泰[1] ZHANG Kaitai(Cancer Hospital,Chinese Academy of Medical Sciences/National Cancer Center,Beijing 100021,China)

机构地区：[1]中国医学科学院肿瘤医院/国家癌症中心,北京100021

出　　处：《癌变．畸变．突变》2024年第3期169-171,共3页Carcinogenesis,Teratogenesis & Mutagenesis

摘　　要：免疫衰老是人体自然衰老的一部分,也是影响整体衰老进程的关键环节。恶性肿瘤作为老年性疾病,普遍存在严重的免疫衰老现象。除免疫系统的自然衰老外,肿瘤细胞可进一步加速免疫衰老,导致免疫系统年轻细胞减少,老化细胞增多,抗肿瘤免疫功能低下。阻断恶性肿瘤与免疫衰老的相互诱导,逆转免疫衰老对于控制肿瘤、实现长期带瘤生存具有积极意义。Immunosenescence is an inherent and crucial aspect of the aging process.Malignant tumors which often develop among senior individuals are associated with immunosenescence.Besides the immune systems intrinsic aging,cancerous cells can exacerbate immunosenescence.This combination can lead to a reduction of young immune cells and an increase of older immune cells.Consequently,the immune system would have reduced ability to combat tumors.Interrupting the reciprocal interaction between malignant tumors and immunosenescence,as well as reversing the effects of immunosenescence,can hold promise for enhancing antitumor responses and improving long-term survival of cancer patients.

关 键 词：恶性肿瘤 免疫衰老 带瘤生存 老化细胞 

分 类 号：R730.2[医药卫生—肿瘤]