加味黄芪桂枝五物汤预防奥沙利铂致胃癌患者周围神经毒性的临床观察  被引量:3

Clinical Effect of Jiawei Huangqi Guizhi Wuwu Decoction in Preventing Peripheral Neurotoxicity Induced by Oxaliplatin in Patients with Gastric Cancer

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作  者:刘磊 郑磊 张梅[2] 张家乐 于东风[1] LIU Lei;ZHENG Lei;ZHANG Mei;ZHANG Jiale;YU Dongfeng(Department of General Surgery,The First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230031,China;Department of Integrated Traditional Chinese and Western Medicine Oncology,The First Affiliated Hospital of Anhui Medical University,Anhui Hefei 230031,China)

机构地区:[1]安徽医科大学第一附属医院普外科,安徽合肥230031 [2]安徽医科大学第一附属医院中西医结合肿瘤科,安徽合肥230031

出  处:《安徽中医药大学学报》2024年第3期17-20,共4页Journal of Anhui University of Chinese Medicine

基  金:安徽省红十字会中医药传承创新发展研究项目(2021ZYYB16)。

摘  要:目的观察加味黄芪桂枝五物汤对奥沙利铂致胃癌患者周围神经毒性的临床疗效。方法将60例使用奥沙利铂的胃癌患者分为对照组和观察组,每组30例。对照组予以奥沙利铂化学治疗,观察组在对照组基础上予以加味黄芪桂枝五物汤,共治疗4个月。治疗后采用Levi分级标准比较两组周围神经毒性,同时比较两组消化道不良反应发生率、血液毒性、肝功能异常率和肿瘤标志物升高率。结果观察组患者Levi分级明显低于对照组(P<0.05),消化道不良反应发生率明显低于对照组(P<0.05);两组患者血液毒性分级(白细胞、血小板和血红蛋白分级),丙氨酸氨基转移酶、天冬氨酸氨基转移酶升高率和肿瘤标志物升高率比较,差异均无统计学意义(P>0.05)。结论加味黄芪桂枝五物汤可以预防和缓解胃癌患者使用奥沙利铂所致的周围神经毒性和消化道不良反应,且安全可靠。Objective To investigate the clinical effect of Jiawei Huangqi Guizhi Wuwu Decoction in preventing peripheral neurotoxicity induced by oxaliplatin in patients with gastric cancer.Methods A total of 60 patients with gastric cancer were enrolled and divided into control group and observation group,with 30 patients in each group.The patients in the control group received oxaliplatin chemotherapy,and those in the observation group received Jiawei Huangqi Guizhi Wuwu Decoction in addition to the treatment in the control group;the course of treatment was 4 months for both groups.Levi grade was used to observe peripheral neurotoxicity after treatment,and the two groups were observed in terms of gastrointestinal adverse reactions,hematologic toxicity,abnormal rate of liver function,and the rate of increase in tumor markers.Results Compared with the control group,the observation group had significantly lower Levi grade(P<0.05)and incidence rate of gastrointestinal adverse reactions(P<0.05).There were no significant differences between the two groups in the grade of hematologic toxicity(leukocytes,platelets,and hemoglobin)and the rates of increase in alanine aminotransferase,aspartate aminotransferase,and tumor markers(P>0.05).Conclusion Jiawei Huangqi Guizhi Wuwu Decoction is safe and reliable in preventing peripheral neurotoxicity and alleviating gastrointestinal adverse reactions due to oxaliplatin in patients with gastric cancer.

关 键 词:黄芪桂枝五物汤 奥沙利铂 周围神经毒性 胃癌 

分 类 号:R735.2[医药卫生—肿瘤] R273[医药卫生—临床医学]

 

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