DRD1在神经系统疾病和功能中的研究进展  

Research Progress of DRD1 in Neurological Disorders and Functions

作　　者：李瑾瑜 冯良升 高扬[1] 李钰 吴帮旭 邹英鹰 LI Jinyu;FENG Liangsheng;GAO Yang;LI Yu;WU Bangxu;ZOU Yingying(The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032;School of Basic Medicine of Kunming Medical University,Kunming Yunnan 650500,China)

机构地区：[1]昆明医科大学第一临床医学院,云南昆明650032 [2]昆明医科大学基础医学院,云南昆明650500

出　　处：《昆明医科大学学报》2024年第5期1-7,共7页Journal of Kunming Medical University

基　　金：国家自然科学基金资助项目(32060184);昆明医科大学大学生创新创业训练基金资助项目(2023CXD267)。

摘　　要：多巴胺D1受体(dopamine D1 receptor,DRD1)是目前已知神经系统表达最广泛的多巴胺受体亚型。DRD1能通过多种信号通路发挥运动、情感、认知、学习记忆以及神经内分泌等功能。这些功能可能与帕金森综合征、精神分裂症、抑郁症等精神疾病以及免疫有关。而DRD1的表达变化通常提示了神经系统功能的改变。因此DRD1可以作为神经系统疾病和功能变化的潜在指标和神经系统疾病治疗的潜在靶点。综述DRD1在神经系统中的分布和功能,重点强调DRD1与神经系统相关的信号通路。Dopamine D1 receptor(DRD1)is currently known as the dopamine receptor subtype with the most widespread expression in the nervous system.DRD1 plays a role in various signaling pathways to perform many functions such as movement,emotion,cognition,learning and memory,as well as neuroendocrine activities.These functions may be associated with conditions like Parkinson's syndrome,schizophrenia,depression,and immune responses.Changes in the expression of DRD1 often indicate alterations in neurological functions.Therefore,DRD1 has the potential to serve as an indicator of neurological disorders and functional changes,as well as a potential target for the treatment of neurological diseases.This article reviews the distribution and functions of DRD1 in the nervous system,with a particular emphasis on DRD1's involvement in signaling pathways related to the nervous system.

关 键 词：多巴胺受体 神经系统 DRD1 多巴胺 

分 类 号：R741.02[医药卫生—神经病学与精神病学]