ROR1在不同组织学分级浸润性肺腺癌中的表达与临床意义  

Expression and Clinical Significance of ROR1 in Different Histologic Types of Invasive Lung Adenocarcinoma

作　　者：沈旺寻 杨银煜 李灿伟 杨金荣[1] 伍思婧 赵华君 陀晓宇 SHEN Wangxun;YANG Yinyu;LI Canwei;YANG Jinrong;WU Sijing;ZHAO Huajun;TUO Xiaoyu(The 1st Clinical Medical College of Kunming Medical University,Kunming Yunnan 650032;Mental Health Center of Kunming Medical University,Kunming Yunnan 650224;Dept.of Pathology,The 1st Affiliated Hospital of Kunming Medical University,Kunming Yunnan 650032,China)

机构地区：[1]昆明医科大学第一临床医学院,云南昆明650032 [2]昆明医科大学附属精神卫生中心,云南昆明650224 [3]昆明医科大学第一附属医院病理科,云南昆明650032

出　　处：《昆明医科大学学报》2024年第5期60-65,共6页Journal of Kunming Medical University

基　　金：国家级大学生创新创业训练计划基金资助项目(202210678020);云南省教育厅科学研究基金资助项目(2024J0206);云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目(202001AY070001-103)。

摘　　要：目的研究受体酪氨酸激酶样孤儿受体1(receptor tyrosine kinase-like orphan rectetpor 1,ROR1)在不同组织学分级的浸润性肺腺癌中的表达情况,分析其与肺腺癌病理组织学分级的关系;探讨其是否可作为浸润性肺腺癌诊断评估的潜在指标。方法收集浸润性肺腺癌石蜡包埋组织标本290例,行HE染色切片后进行组织学分级,通过免疫组化染色,使用半定量法判读ROR1表达水平,统计分析ROR1表达与浸润性肺腺癌分级的关系。结果ROR1高表达于低分化的浸润性肺腺癌(P<0.001);低分化组的浸润性肺腺癌中Ki-67指数明显高于高、中分化组(P<0.001);Ki-67指数在ROR1高表达组高于低表达组(P<0.01)。结论ROR1在不同分级的肺腺癌中表达水平存在明显差异,其表达水平与浸润性肺腺癌的分化程度及恶性程度密切相关,这使得它有可能成为新的肺腺癌诊断生物标志物并辅助肺腺癌的临床特征和预后的评估,为患者制定个性化治疗策略提供科学依据。Objective To investigate the expression of receptor tyrosine kinase-like orphan rectetpor 1(ROR1)in invasive lung adenocarcinoma with different histological grades,and to analyze its relationship with histopathological grade of lung adenocarcinoma so as to explore whether it can be used as a potential indicator for the diagnostic evaluation of invasive lung adenocarcinoma.Methods A total of 290 paraffin-embedded tissue specimens of invasive lung adenocarcinoma were collected,and the relationship between ROR1 expression and invasive lung adenocarcinoma grade was statistically analyzed by HE staining sections.Results ROR1 was significantly highly expressed in the poorly differentiated invasive lung adenocarcinoma(P<0.001),the Ki-67 index in the low-differentiated group was significantly higher than that in the high-differentiation and mediumdifferentiated groups(P<0.001),and the Ki-67 index was higher in the high-expression group than in the lowexpression group(P<0.01).Conclusion There are significant differences in the expression levels of ROR1 in different grades of lung adenocarcinoma,and its expression level is closely related to the degree of differentiation and malignancy of invasive lung adenocarcinoma,which makes it possible to become a new biomarker for the diagnosis of lung adenocarcinoma and assist in the evaluation of clinical features and prognosis of lung adenocarcinoma,and provide a scientific basis to formulate personalized treatment strategies for patients.

关 键 词：肺腺癌 ROR1 KI-67 病理学分级 免疫组化 

分 类 号：R734.2[医药卫生—肿瘤] R366[医药卫生—临床医学] R36