治疗前格拉斯哥评分及血液炎性指标与鼻咽癌患者预后相关性研究  

Study on the correlation between pre-treatment Glasgow score and blood inflammatory markers and prognosis of nasopharyngeal carcinoma patients

作　　者：李晓惠 许啸 范元平 文娟 陈静茹 夏云飞[2,3] LI Xiaohui;XU Xiao;FAN Yuanping;WEN Juan;CHEN Jingru;XIA Yunfei(Department of Oncology,Army 32265,Guangzhou 510318,China;Department of Radiation Oncology,Sun Yat-sen University Cancer Center,Guangzhou 510060,China;Sun Yat-sen University Cancer Center,State Key Laboratory of Oncology in South China,Guangzhou 510060,China)

机构地区：[1]32265部队肿瘤科,广东广州510318 [2]中山大学肿瘤防治中心放疗科,广东广州510060 [3]中山大学肿瘤防治中心华南肿瘤学国家重点实验室,广东广州510060

出　　处：《新医学》2024年第5期328-334,共7页Journal of New Medicine

基　　金：国家高技术研究发展计划(863计划)(2006AA0224B4);广东省医学科学技术研究基金项目(A2018552,B2022288)。

摘　　要：目的探讨治疗前格拉斯哥预后评分(GPS)及血液炎性指标与鼻咽癌患者预后相关性。方法将来自2个临床中心的鼻咽癌患者428例分成训练集和验证集,比较2组临床特征是否均衡。在训练集中分析治疗前GPS及血液炎性指标对鼻咽癌患者5年疾病特异生存率的影响,寻找鼻咽癌独立预后危险因素,并计算每位患者的预后指数,将其分为低危、中危和高危组。在验证集中进一步验证。结果训练集Cox多因素分析发现治疗前年龄>50岁、T分期T3~T4、N分期N2~N3、GPS 1~2分、中性粒细胞与淋巴细胞比值(NLR)>2.5、淋巴细胞与单核细胞比值(LMR)≤2.35是影响鼻咽癌患者5年疾病特异生存率的不良预后因素,验证集得以验证。结论治疗前GPS、NLR、LMR等联合年龄、TNM分期可能为鼻咽癌患者预后评估提供了新途径。Objective To investigate the correlation between Glasgow score and blood inflammatory markers before treatment with the efficacy of nasopharyngeal carcinoma.Methods Cases from the two clinical centers were divided into training set and validation set,and the clinical characteristics of the two groups were compared to be balanced.To search the independent prognostic risk factors of nasopharyngeal carcinoma and then the prognostic index of each patient was calculated,and the patients were divided into high-risk,intermediate-risk and low-risk groups.Further validation in the validation set.Results Cox multivariate analysis of the training set showed that age>50,T_(3)-T_(4),N2-N3,GPS score of 1-2,NLR>2.5,and LMR≤2.35 before treatment were poor prognostic factors affecting the 5-year disease-specific survival rate of patients with nasopharyngeal carcinoma.Conclusion The combination of GPS,NLR,LMR and age,TNM staging may provide a new way for the prognosis evaluation of patients with nasopharyngeal carcinoma before treatment.

关 键 词：鼻咽癌 中性粒细胞与淋巴细胞比值 格拉斯哥预后评分 血小板与淋巴细胞比值 淋巴细胞与单核细胞比值 

分 类 号：R739.63[医药卫生—肿瘤]