p-IRE1、β-catenin及XIAP在鼻腔鼻窦内翻性乳头状瘤临床诊断及预后评估中的意义  

Significance of p⁃IRE1,β⁃catenin and XIAP in clinical diagnosis and prognosis assessment of inverted papilloma of the nasal cavity and sinuses

作　　者：任颖川[1] 袁晓辉[1] 胡滢洁 REN Yingchuan;YUAN Xiaohui;HU Yingjie(Department of Otolaryngology,Pingdingshan First People's Hospital,Pingdingshan,Henan,China,467000)

机构地区：[1]平顶山市第一人民医院耳鼻喉科,河南平顶山467000

出　　处：《分子诊断与治疗杂志》2024年第4期625-629,共5页Journal of Molecular Diagnostics and Therapy

基　　金：河南省医学科技攻关项目(LHGJ20223566)。

摘　　要：目的探讨磷酸化需肌醇酶1蛋白(p-IRE1)、β-连环素(β-catenin)及X连锁凋亡抑制蛋白(XIAP)在鼻腔鼻窦内翻性乳头状瘤(SNIP)中的表达及其在临床诊断和预后评估中的意义。方法选取2017年1月至2022年1月平顶山市第一人民医院收治的SNIP患者102例为SNIP组;另选取本院同时间段因鼻中隔偏曲对侧下鼻甲代偿性肥大而行下鼻甲黏膜部分切除术的患者99例,经病理确诊为正常鼻腔黏膜组织(设为对照组)。比较两组组织中p-IRE1、β-catenin及XIAP的表达强度情况;102例SNIP患者出院后,行2年门诊复查随访,比较SNIP组不同预后情况患者一般资料及p-IRE1、β-catenin及XIAP阳性表达;采用多元Logistic回归模型分析影响SNIP患者预后的危险因素。结果两组间p-IRE1、β-catenin及XIAP表达强度比较,差异具有统计学意义(P<0.05);且SNIP组p-IRE1、β-catenin及XIAP阳性率高于对照组,差异均有统计学意义(P<0.05)。据随访统计,预后良好组81例,预后不良好组21例。两组性别、年龄比较,差异无统计学意义(P>0.05);两组Krouse临床分期、病理分化程度、p-IRE1、β-catenin及XIAP阳性表达比较,差异具有统计学意义(P<0.05)。多元Logistic回归模型结果显示,Krouse临床分期为T_3期-T_4期、病理分化程度伴恶变SNIP、p-IRE1、β-catenin及XIAP表达为阳性均是影响SNIP患者的预后不良的危险因素(P<0.05)。结论在SNIP组织中,p-IRE1、β-catenin及XIAP的表达强度及阳性表达率均显著高于正常鼻腔黏膜组织;通过检测上述指标阳性表达,可以预测SNIP预后情况,有利于SNIP后续治疗。Objective To explore phosphorylated inositase⁃1 protein(p⁃IRE1),β⁃catenin(Beta⁃catenin),and X⁃linked apoptosis inhibitor protein(XIAP)expression in inverted papilloma of the nasal cavity and sinuses(SNIP)and its significance in clinical diagnosis and prognosis evaluation.Methods A total of 102 patients with SNIP admitted to the First Peoples Hospital of Pingdingshan City from January 2017 to Janu⁃ary 2022 were selected for the SNIP group.Nasal sinus involutional papilloma tissues were obtained for patho⁃logical diagnosis.Another group was chosen during the same period at our hospital for septal deviation or con⁃tralateral inferior turbinate compensatory hypertrophy,who underwent partial excision of the inferior turbinate mucous membrane.The pathology confirmed the normal nasal mucous membrane tissues for this control group.To compare the expression levels of p⁃IRE1,β⁃catenin and XIAP in the tissues of both groups,102 SNIP pa⁃tients were discharged from the hospital and followed up as outpationt for 2⁃years.The study aimed to compare the prognosis of SNIP patients based on general information and the positive expression of p⁃IRE1,β⁃catenin and XIAP.Additionally,a multivariate logistic regression model was used to analyze the risk factors influenc⁃ing the prognosis of SNIP patients.Results Comparison of the levels of p⁃IRE1,β⁃catenin and XIAP expres⁃sion between the two groups showed statistically significant differences(P<0.05).The positive rates of p⁃IRE1,β⁃catenin and XIAP in the SNIP group were higher than those in the control group,with statistically significant differences(P<0.05).According to the follow⁃up statistics,there were 81 cases in the good progno⁃sis group and 21 cases in the poor prognosis group.Comparing the gender and age of the two groups,the dif⁃ference was not statistically significant(P>0.05).However,when comparing the clinical stage of Krouse,the degree of pathological differentiation,and the positive expression of p⁃IRE1,β⁃catenin and

关 键 词：磷酸化需肌醇酶1蛋白 Β-连环素 X连锁凋亡抑制蛋蛋白 鼻腔鼻窦内翻性乳头状瘤 

分 类 号：R739.62[医药卫生—肿瘤]