慢性乙型肝炎肝硬化患者LN、CHE及TRF表达水平与病情的关系  

Relationship between the expression levels of LN,CHE and TRF in cirrhotic liver cirrhosis and disease in chronic hepatitis B

作　　者：蔡峻岭 苏立 郝丽 赵敏 CAI Junling;SU Li;HAO Li;ZHAO Min(Department of Infectious Diseases,Zhumadian Central Hospital,Zhumadian,Henan,China,463000)

机构地区：[1]驻马店市中心医院感染科,河南驻马店463000

出　　处：《分子诊断与治疗杂志》2024年第4期739-742,共4页Journal of Molecular Diagnostics and Therapy

基　　金：河南省科技发展计划项目(222102310272)。

摘　　要：目的探究LN、CHE及TRF表达水平与CHBC患者病情程度间的关系。方法选取2021年2月至2022年12月驻马店市中心医院收治的168例CHBC患者为研究对象(CHB肝硬化组),另选取同期未合并肝硬化的CHB患者152例(CHB组)、健康体检人群161名(对照组)。比较三组LN、CHE、TRF、HA、Ⅳ-C、PCⅢ水平,分析CHBC组LN、CHE及TRF水平与肝纤维化指标的相关性,采用ROC曲线分析LN、CHE、TRF单独及联合检测评估CHBC患者肝纤维化的效能。结果CHBC组LN、HA、Ⅳ-C、PⅢP水平均高于对照组和CHB组,CHE、TRF水平均低于对照组和CHB组,差异有统计学意义(P<0.05);重度肝硬化组LN、HA、Ⅳ-C、PⅢP水平均高于轻度肝硬化组、中度肝硬化组,CHE、TRF水平均低于轻度肝硬化组、中度肝硬化组,差异有统计学意义(P<0.05);经Pearson分析,LN水平与HA、Ⅳ-C、PCⅢ水平之间呈正相关性,CHE、TRF水平与HA、Ⅳ-C、PCⅢ水平之间呈负相关性(P<0.05);ROC曲线显示,LN、CHE、TRF联合检测CHBC患者肝纤维化的AUC为0.902,高于三者单独检测的0.742、0.837、0.739。结论LN、CHE及TRF表达水平与CHBC患者肝纤维化有密切联系,三者联合检测对CHBC患者肝纤维化具有较好的评估价值,对临床CHBC病情评估有一定指导作用。Objective To explore the relationship between the expression levels of LN,CHE,and TRF and the severity of liver cirrhosis in patients with chronic hepatitis B(CHB),and to provide new insights for clinical diagnosis and treatment.Methods 168 patients with CHB cirrhosis admitted to Zhumadian Central Hospital from February 2021 to December 2022 were selected for the study(CHBC group),and 152 patients with CHB without combined cirrhosis in the same period(CHB group)and 161 people in the population with health checkups(control group)were also selected.The purpose of the study was to compare the levels of LN,CHE,TRF,HA,IV⁃C and PCⅢin the three groups,and to analyze the correlation between the levels of LN,CHE and TRF and liver fibrosis indexes in the CHBC group,and the efficacy of LN,CHE and TRF alone and in combined assays in assessing liver fibrosis in CHBC patients by using ROC curves.Results The levels of LN,HA,Ⅳ⁃C and PⅢP in the CHBC group were higher than those in the control group and the CHB group,while the levels of CHE and TRF were lower than those in the control group and the CHB group,showing statis⁃tically significant differences(P<0.05).The levels of LN,HA,Ⅳ⁃C and PⅢP in the severe cirrhosis group were higher than those in the mild cirrhosis group and the moderate cirrhosis group,and the levels of CHE and TRF in the CHBC group were lower than those in the mild cirrhosis group and moderate cirrhosis group,and the difference was statistically significant(P<0.05).According to Pearsons analysis,there was a positive correlation between the LN level and the levels of HA,Ⅳ⁃C,and PCⅢ,and a negative correlation between the levels of CHE and TRF and the levels of HA,Ⅳ⁃C,and PCⅢ(P<0.05).The ROC curves showed that the AUC of the combined detection of liver fibrosis in patients with cirrhosis of CHB by LN,CHE,and TRF was 0.902,which was higher than that of the three individually(0.742,0.837,and 0.739).Conclusion The expression levels of LN,CHE,and TRF are closely related to liver fibrosis

关 键 词：慢性乙型肝炎肝硬化 层粘连蛋白 胆碱酯酶 转铁蛋白 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]