血清P53、G-17及MG7-Ag检测联合胃镜下病理检查在胃癌及癌前病变诊断中的应用  

Serum P53,G⁃17 and MG7⁃Ag testing combined with gastroscopic pathology in the diagnosis of gastric cancer and precancerous lesions

作　　者：荆玉洁 段振刚 李妮 姚茹 JING Yujie;DUAN Zhengang;LI Ni;YAO Ru(Department of Gastroenterology,Air Force 986th Hospital,Xi'an,Shaanxi,China,710054)

机构地区：[1]空军第九八六医院消化内科,陕西西安710054

出　　处：《分子诊断与治疗杂志》2024年第5期913-916,共4页Journal of Molecular Diagnostics and Therapy

基　　金：陕西省重点研发计划项目(S2023-YF-YBSF-0438)。

摘　　要：目的研究血清P53抑癌基因、胃泌素-17(G-17)及人胃癌抗原MG7(MG7-Ag)检测联合胃镜下病理检查在胃癌及癌前病变诊断中的应用效果。方法本研究采用回顾性的方法,选取2022年3月至2023年1月空军第九八六医院收治的经胃镜检查诊断为胃早癌或癌前病变患者152例为研究对象。统计病理诊断结果;比较胃癌组与癌前病变组血清P53、G-17及MG7-Ag水平;以病理诊断为金标准,分析胃镜检查表现与金标准的一致性;采用ROC曲线评估血清P53、G-17及MG7-Ag水平联合胃镜下病理检查对胃癌癌前病变的诊断价值。结果152例疑似胃早癌及癌前病变患者经病理学诊断,发现胃癌患者75例(49.35%);胃癌癌前病变患者77例(50.65%),其中肠上皮化36例(23.68%),萎缩性胃炎30例(19.74%)及胃溃疡11例(7.24%)。胃癌组G-17及MG7-Ag水平高于癌前病变组,P53阳性表达例数多于癌前病变组,差异有统计学意义(P<0.05)。152例疑似胃早癌及癌前病变患者经胃镜检查,发现胃癌患者70例(46.05%);胃癌癌前病变患者82例(53.95%),其中肠上皮化36例(23.68%),萎缩性胃炎32例(21.05%)及胃溃疡14例(9.21%)。ROC曲线显示,胃镜+P53+G-17+MG7-Ag联合检测诊断胃癌癌前病变的灵敏度、特异度分别为92.55%、91.18%,明显高于三者单独检测(P<0.05)。结论血清P53、G-17及MG7-Ag与胃癌及癌前病变的发生、发展有密切联系,且上述血清检测联合胃镜下病理检查诊断胃癌及癌前病变的准确率更高。Objective To study the effect of serum P53 oncogene(P53),gastrin⁃17(G⁃17)and human gastric cancer antigen MG7(MG7⁃associated glycoprotein,MG7⁃Ag)detection combined with gastro⁃scopic pathological examination in the diagnosis of gastric cancer and precancerous lesions.Methods In this study,152 patients with early gastric cancer or precancerous lesions diagnosed by gastroscopy were selected using a retrospective method at the Ninety⁃eight Sixth Hospital of the Air Force from March 2022 to January 2023.The study included statistical results of pathological diagnoses,a comparison of serum P53,G⁃17 and MG7⁃Ag levels between the gastric cancer group and the precancerous lesion group,an analysis of the consis⁃tency between gastroscopic examination performance and the gold standard of pathological diagnosis,and an assessment of the diagnostic value of serum P53,G⁃17 and MG7⁃Ag levels combined with gastroscopic patho⁃logical examination for precancerous lesions of gastric cancer using ROC curve analysis.Results After a path⁃ological diagnosis of 152 patients with suspected early gastric cancer and precancerous lesions,it was found that 75 patients(49.35%)had gastric cancer,while 77 patients(50.65%)had precancerous lesions of gastric cancer.Among those with precancerous lesions,36 patients(23.68%)had intestinal epithelialization,30 pa⁃tients(19.74%)had atrophic gastritis and 11 patients(7.24%)had gastric ulcers.The levels of G⁃17 and MG7⁃Ag in the gastric cancer group were higher than those in the precancerous lesion group.Additionally,the num⁃ber of cases with P53 positive expression was greater in the gastric cancer group compared to the precancerous lesion group,with a statistically significant difference(P<0.05).After a gastroscopic examination of the same 152 patients,it was discovered that 70 patients(46.05%)had gastric cancer,while 82 patients(53.95%)had precancerous gastric cancer.Among those with of precancerous lesions,36 patients(23.68%)had intestinal epithelialization,32 patien

关 键 词：P53 G-17 MG7-AG 胃镜下病理检查 胃癌 癌前病变 

分 类 号：R735.2[医药卫生—肿瘤]