口腔颅颌面系统组织再生的发展与研究现状  

Advancements and current research in orofacial tissue regeneration

作　　者：毛学理[1] 施松涛 Mao Xueli;Shi Songtao(South China Center of Craniofacial Stem Cell Research,Hospital of Stomatology,Guanghua School of Stomatology,Sun Yat-sen University&Guangdong Provincial Key Laboratory of Stomatology,Guangzhou 510055,China)

机构地区：[1]中山大学附属口腔医院华南颅颌干细胞转化研究中心·中山大学光华口腔医学院·广东省口腔医学重点实验室,广州510055

出　　处：《中华口腔医学杂志》2024年第5期407-417,共11页Chinese Journal of Stomatology

基　　金：国家重点研发计划(2021YFA1100600)。

摘　　要：口腔颅颌面系统是包含多种组织的复杂综合性系统,具有独特的生物学特征,并赋予个体形貌,口腔颅颌面系统组织缺损后的再生具有重要意义,也是当前口腔医学领域的一项重大挑战。本文回顾口腔颅颌面系统组织再生领域的研究历程,总结当前研究的现状和面临的问题,聚焦口腔颅颌面系统间充质干细胞在组织再生中的关键作用,并对未来该领域的发展进行探讨和展望,旨在增进口腔医学工作者对本领域的了解,并为口腔颅颌面系统组织再生领域的创新性治疗方法和临床实践提供可能的方向。The orofacial system,an intricate assembly of diverse tissues that underpin the unique biologic and morphological identity of an individual,presents a formidable challenge in the realm of tissue regeneration within oral and maxillofacial surgery.This review conducts a retrospective appraisal of advancements in the field of orofacial tissue regeneration,elucidating the current research landscape while critically addressing the persisting challenges.It underscores the pivotal roles of orofacial mesenchymal stem cells in orchestrating regenerative processes,offering an insightful outlook on future developments.The objective is to demarcate innovative therapeutic avenues and clinical implications by fostering a comprehensive understanding of this domain among dental practitioners.As such,it aspires to serve as a valuable reference for prospective investigations and to elevate the knowledge base pertaining to orofacial tissue regeneration.

关 键 词：再生医学 组织工程 口腔颅颌面系统 间充质干细胞 牙髓 牙周组织 

分 类 号：R78[医药卫生—口腔医学]