组蛋白乙酰化修饰在颅颌面硬组织发育和再生中的作用  

Histone acetylation in the development and regeneration of craniofacial hard tissue

作　　者：蒋欣泉[1] Jiang Xinquan(Department of Prosthodontics,Shanghai Ninth People′s Hospital,Shanghai Jiao Tong University School of Medicine&College of Stomatology,Shanghai Jiao Tong University&National Center for Stomatology&National Clinical Research Center for Oral Diseases&Shanghai Key Laboratory of Stomatology&Shanghai Research Institute of Stomatology,Shanghai 200011,China)

机构地区：[1]上海交通大学医学院附属第九人民医院口腔修复科、上海交通大学口腔医学院、国家口腔医学中心、国家口腔疾病临床医学研究中心、上海市口腔医学重点实验室、上海市口腔医学研究所,上海200011

出　　处：《中华口腔医学杂志》2024年第5期426-434,共9页Chinese Journal of Stomatology

基　　金：国家重点研发计划(2023YFC2413600);国家自然科学基金(81921002)。

摘　　要：口腔颅颌面硬组织主要包括颅颌面骨及牙齿组织,是口腔颅颌面系统的重要组成部分。发育畸形、肿瘤、外伤等疾病可造成颅颌面硬组织大面积缺损,严重损害患者面部形貌与功能,影响患者生活质量与身心健康。组蛋白乙酰化修饰是研究最早、最广的组蛋白修饰方式,是由组蛋白乙酰转移酶和组蛋白去乙酰化酶共同调控的表观遗传修饰机制。本文对组蛋白乙酰转移酶和组蛋白去乙酰化酶介导的组蛋白乙酰化修饰在颅颌面硬组织发育与再生修复中的研究现状进行评述。Craniofacial hard tissue mainly includes craniofacial bone and tooth,which is one of the important parts of the mouth-jaw system.Congenital aplasia,tumors and trauma can cause large craniofacial hard tissue defects,which are detrimental to the facial appearance and function of patients,and affect the physical and mental health of patients.Histone acetylation modification is the earliest and most widely studied histone modification,which is an epigenetic modification mechanism jointly regulated by histone acetyltransferase and histone deacetylase.In this paper,we will review the research progress of histone acetylation mediated by histone acetyltransferase and histone deacetylase in the development and regeneration of craniofacial hard tissue.

关 键 词：再生医学 组蛋白乙酰化 颅颌面硬组织 表观遗传调控 

分 类 号：R782[医药卫生—口腔医学]