牙髓干细胞用于牙再生的新进展和新方向  

Dental pulp stem cells in tooth regeneration:advancement and emerging directions

作　　者：马琳 刘安琪 郭皓 轩昆 Ma Lin;Liu Anqi;Guo Hao;Xuan Kun(Department of Preventive Dentistry,School of Stomatology,The Fourth Military Medical University,State Key Laboratory of Oral&Maxillofacial Reconstruction and Regeneration,National Clinical Research Center for Oral Diseases,Shaanxi Clinical Research Center for Oral Diseases,Xi′an 710032,China;Department of Stomatology,985 Hospital of Joint Logistics Support Force,Taiyuan 030000,China)

机构地区：[1]第四军医大学口腔医院口腔预防科、口颌系统重建与再生全国重点实验室、国家口腔疾病临床医学研究中心、陕西省口腔疾病临床医学研究中心,西安710032 [2]中国人民解放军联勤保障部队第九八五医院口腔科,太原030000

出　　处：《中华口腔医学杂志》2024年第5期496-501,共6页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82100992,82370949)。

摘　　要：获得正常形态结构和功能的牙髓、牙本质和牙周再生一直是牙再生领域的研究热点。目前,以牙髓干细胞为种子细胞的组织工程与再生技术已初步实现类牙组织再生。如何提高再生的有效性和稳定性成为亟待解决的问题。单细胞转录组测序和类器官培养技术的发展,为进一步实现精准、靶向和可控的功能性牙再生提供了可能。本文综述牙髓干细胞在牙再生中的研究进展,归纳牙髓干细胞基本特性并浅析研究热点,为实现稳定高效的牙再生提供新的研究方向和转化应用思路。Regenerating tissues similar to dental structure with normal function are putatively to be the aim in tooth regeneration filed.Currently,researchers preliminarily achieved tooth regeneration by applying dental pulp stem cells(DPSC)and stem cells from human exfoliated deciduous teeth(SHED).However,the regeneration efficiency remains unstable and needs further investigation.The development of single-cell RNA sequencing and organoid culture system provide potential of precise,targeted and controllable functional regeneration.This article reviews the current state of DPSC/SHED on tooth regeneration,and analyzes characteristics and hotspots of them,aiming to shed light on clinical translational application of stable and efficient tooth regeneration.

关 键 词：再生医学 牙髓干细胞 乳牙牙髓干细胞 牙再生 单细胞转录组测序 

分 类 号：R781[医药卫生—口腔医学]