甲基化修饰在牙根发育中作用的研究进展  

Research progress in methylation modification in tooth root development

作　　者：甘鑫琰 李奇文 袁泉[1] Gan Xinyan;Li Qiwen;Yuan Quan(Department of Oral Implantology,West China Hospital of Stomatology,Sichuan University&State Key Laboratory of Oral Diseases&National Center for Stomatology&National Clinical Research Center for Oral Diseases,Chengdu 610041,China)

机构地区：[1]四川大学华西口腔医院种植科、口腔疾病防治全国重点实验室、国家口腔医学中心、国家口腔疾病临床医学研究中心,成都610041

出　　处：《中华口腔医学杂志》2024年第5期502-506,共5页Chinese Journal of Stomatology

基　　金：国家自然科学基金(82125006)。

摘　　要：甲基化修饰是真核生物中最常见的表观修饰调控,包括组蛋白甲基化、DNA甲基化、RNA甲基化等,在生理和病理过程中发挥重要的调控作用。牙根发育由上皮和间充质细胞共同完成,涉及多种细胞与分子的相互作用。近年大量研究显示,甲基化修饰对牙根发育发挥关键调控作用,这逐渐拓展了牙根发育的调控机制网络。本文综述牙根发育过程中甲基化修饰的作用和机制研究新进展,以期为牙根缺失或短根畸形诊治提供新的理论基础。Methylation modification is one of the most common epigenetic modification regulation in eukaryotes,including histone methylation,DNA methylation,RNA methylation,etc.,which plays an important regulatory role in physiological processes and pathologic occurrence and development.Tooth root development is carried out by both epithelial and mesenchymal cells and involves a variety of cell-molecular interactions.In recent years,a large number of studies have found that methylation plays a key role in the regulation of tooth root development and expands the mechanism network of tooth root development.In this paper,we review the role and mechanism of methylation modification during root development.

关 键 词：牙根 甲基化 组蛋白类 DNA修饰甲基酶类 表观遗传 

分 类 号：R781[医药卫生—口腔医学]