眼部Merkel细胞癌临床特征及研究进展  

Clinical characteristics and research progress of ocular Merkel cell carcinoma

作　　者：张硕 姜利斌 Zhang Shuo;Jiang Libin(Beijing Tongren Eye Center,Beijing Tongren Hospital,Capital Medical University,Beijing Institute of Ophthalmology,Beijing Key Laboratory of Ophthalmology&Visual Sciences,Beijing 100730,China)

机构地区：[1]首都医科大学附属北京同仁医院北京同仁眼科中心,北京市眼科研究所,北京市眼科学与视觉科学重点实验室,北京100730

出　　处：《中华眼科杂志》2024年第5期467-471,共5页Chinese Journal of Ophthalmology

基　　金：北京市自然科学基金(7222028)。

摘　　要：Merkel细胞癌(MCC)是一种罕见的、具有侵袭性的上皮性和神经内分泌性肿瘤。MCC通常表现为阳光暴露皮肤区域快速生长的无痛性结节或斑块。眼部MCC约占所有患者的2.5%,可能被误诊为霰粒肿或基底细胞癌。发病的危险因素包括高龄、紫外线暴露、男性、免疫抑制及Merkel细胞多瘤病毒感染。广泛局部切除辅以放射治疗是其治疗方法之一,化学治疗通常用于出现转移的情况,免疫和靶向疗法目前正处于研究阶段,已展现出不错的前景。本文总结了眼部MCC的临床特征及研究进展。Merkel cell carcinoma(MCC)is a rare,aggressive epithelial and neuroendocrine tumor.MCC typically presents as painless nodules or patches rapidly growing in sun-exposed skin areas.Ocular MCC accounts for approximately 2.5%of all cases and may be misdiagnosed as granuloma or basal cell carcinoma.Risk factors for development include advanced age,ultraviolet exposure,male gender,immunosuppression,and Merkel cell polyomavirus infection.Treatment involves wide local excision with adjuvant radiotherapy,chemotherapy is typically reserved for metastatic disease,and immunotherapy and targeted therapy are currently under investigation showing promising early outcomes.This article summarizes the clinical characteristics and research progress of ocular MCC.

关 键 词：癌 Merkel细胞 眼肿瘤 眼睑肿瘤 梅克尔细胞多瘤病毒 多瘤病毒感染 

分 类 号：R73[医药卫生—肿瘤]