超声造影引导射频消融治疗肝癌疗效的meta分析  

Efficacy of radiofrequency ablation guided by contrast-enhanced ultrasound in the treatment of liver cancer:a meta-analysis

作　　者：彭梓婷 石统东[1] PENG Ziting;SHI Tongdong(Infection and Liver Disease Center,the Second Affiliated Hospital of Chongqing Medical University,Chongqing 401336,China)

机构地区：[1]重庆医科大学第二附属医院感染与肝病中心,重庆401336

出　　处：《重庆医学》2024年第10期1548-1552,共5页Chongqing medicine

摘　　要：目的采用meta分析方法评价超声造影引导射频消融治疗肝癌的疗效及安全性。方法检索收集Pubmed、Embase、Web of Science、Cochrane Library、中国知网(CNKI)、维普、万方数据库建库至2023年7月20日发表的有关应用超声造影引导射频消融(试验组)与常规超声或增强CT引导射频消融(对照组)治疗肝癌的临床对照试验研究,将纳入的数据进行meta分析。结果共纳入文献8篇,共879例患者。meta分析显示,两组肿瘤完全消融率(OR=2.96,95%CI:2.13~4.11,P<0.01)、复发率(OR=0.35,95%CI:0.22~0.55,P<0.01)、术后并发症发生率(OR=0.49,95%CI:0.32~0.76,P<0.01)差异有统计学意义。结论超声造影引导射频消融治疗肝癌较常规超声或增强CT疗效更明显。Objective To evaluate the efficacy and safety of contrast-enhanced ultrasound-guided radiofrequency ablation in the treatment of liver cancer by meta-analysis.Methods The clinical controlled trial studys on the application of contrast-enhanced ultrasound guided radiofrequency ablation(the experimental group)and conventional ultrasound and enhanced CT guided radiofrequency ablation(the control group)for liver cancer published in the databases of Pubmed Embase,Web of Science,Cochrane Library,China National Knowledge Infrastructure(CNKI),VIP,and Wanfang were retrieved.The search period was from database establishment to July 20,2023.meta-analysis on the included datas were performed.Results A total of eight studies involving 879 patients were included.Meta-analysis showed that there were significant differences in the complete ablation rate(OR=2.96,95%CI:2.13-4.11,P<0.01),recurrence rate(OR=0.35,95%CI:0.22-0.55,P<0.01)and postoperative complications(OR=0.49,95%CI:0.32-0.76,P<0.01)between the two groups.Conclusion Contrast-enhanced ultrasound guided radiofrequency ablation is more effective than conventional ultrasound or enhanced CT in the treatment of liver cancer.

关 键 词：肝癌 超声造影 射频消融 完全消融率 META分析 

分 类 号：R735.7[医药卫生—肿瘤]