IL-18 sTLT-1及miR-25对脑梗死复发风险的预测价值  

Predictive value of IL-18,s TLT-1 and mi R-25 on the risk of recurrence of cerebral infarction

作　　者：向文杰 梁勇 毛文 XIANG Wenjie;LIANG Yong;MAO Wen(3201 Hospital,Hanzhong 723000,china)

机构地区：[1]三二〇一医院,陕西汉中723000

出　　处：《中国实用神经疾病杂志》2024年第5期563-567,共5页Chinese Journal of Practical Nervous Diseases

基　　金：通用医疗科研基金项目(编号:TYYLKYJJ-2022-005)。

摘　　要：目的探讨miR-25、白细胞介素18(IL-18)、可溶性髓样细胞触发受体样转录因子-1(sTLT-1)在脑梗死患者复发中的预测价值。方法 选取三二〇一医院收治的154例脑梗死患者为脑梗死组,对脑梗死组患者随访1 a,根据是否复发分为复发组和非复发组,比较2组临床资料及血清miR-25、IL-18及s TLT-1表达情况。单因素和Logistic回归分析影响患者复发的独立危险因素。采用ROC曲线分析miR-25、IL-18、sTLT-1在预测患者复发中的临床价值。结果 脑梗死组共46例患者出现复发,相较于未复发组,复发组miR-25[32.00(23.31,34.68)比11.89(7.67,19.39)]、IL-18[(44.75±12.38)ng/L比(23.36±10.49)ng/L]及sTLT-1[(484.61±83.90)ng/L比(325.72±99.17)ng/L]水平更高(P<0.05)。单因素及多因素Logistic回归分析显示,吸烟史、高血压史、miR-25≥11.89、IL-18≥23.36 ng/L、sTLT-1≥325.72 ng/L是影响患者复发的独立危险因素。ROC曲线显示,当miR-25截断值为20.97、IL-18截断值为28.92 ng/L、sTLT-1截断值为388.03 ng/L时预测患者复发的AUC均>0.700。结论 脑梗死复发患者血清miR-25、IL-18及sTLT-1水平显著上升,且miR-25、IL-18及sTLT-1水平在预测脑梗死患者复发中具有一定临床价值。Objective To investigate the predictive value of miR-25,interleukin 18(IL-18),and soluble triggering receptor expressed on myeloid cells-like transcript-1(s TLT-1)in the recurrence of patients with cerebral infarction.Methods A total of 154 patients with cerebral infarction who were treated in the 3201 Hospital were selected as the cerebral infarction group.The patients in the cerebral infarction group were followed up for 1 year,and were divided into the recurrence group and the non-recurrence group according to whether they recurred.The clinical data,and serum miR-25(32.00(23.31,34.68)vs 11.89(7.67,19.39)),IL-18((44.75±12.38)ng/L vs(23.36±10.49)ng/L)and s TLT-1((484.61±83.90)ng/L vs(325.72±99.17)ng/L)expression of the two groups were compared.Univariate and Logistic regression analysis were used to investigate the independent risk factors for recurrence.The clinical value of mi R-25,IL-18 and s TLT-1 in predicting the recurrence of patients was analyzed by ROC curve.Results A total of 46 patients in the cerebral infarction group recurred.Compared with the non-recurrence group,the levels of miR-25,IL-18 and s TLT-1 were higher than those in the recurrence group(P<0.05).Univariate and multivariate Logistic regression analysis showed that smoking history,hypertension history,miR-25≥11.89,IL-18≥23.36 ng/L,sTLT-1≥325.72 ng/L were independent risk factors for patients with recurrence.ROC curve results showed that when miR-25 cut-off value was 20.97,IL-18 cut-off value was 28.92 ng/L,and s TLT-1 cut-off value was 388.03 ng/L,the AUC of predicted patients with recurrence was all greater than 0.700.Conclusion The serum levels of mi R-25,IL-18 and s TLT-1 in patients with recurrent cerebral infarction are significantly increased,and the levels of mi R-25,IL-18 and sTLT-1 have certain clinical value in predicting the recurrence of cerebral infarction.

关 键 词：脑梗死 miR-25 白介素18 可溶性髓样细胞触发受体样转录因子-1 复发 

分 类 号：R743.33[医药卫生—神经病学与精神病学]