阑尾源性腹膜假黏液瘤伴卵巢转移的临床病理特征及预后分析  

Analysis of pathological features and prognosis of peritoneum pseudomyxoma from appendix with ovarian metastasis

作　　者：卢冬梅[1] 马瑞卿[2] Lu Dongmei;Ma Ruiqing(Aerospace Center Hospital,Department of Health Management,Beijing 100049,China;Aerospace Center Hospital,Department of Myxoma,Beijing 100049,China)

机构地区：[1]航天中心医院健康管理部,北京100049 [2]航天中心医院黏液瘤科,北京100049

出　　处：《中华转移性肿瘤杂志》2022年第2期136-141,共6页Chinese Journal of Metastatic Cancer

基　　金：北京海淀区卫生健康发展科研培育计划(HP2021-04-50704)。

摘　　要：目的腹膜假黏液瘤(PMP)是一种主要来源于阑尾黏液性肿瘤的临床症候群。本研究旨在研究卵巢转移情况对阑尾源性PMP女性患者长期预后的影响。方法回顾性分析航天中心医院2008—2019年间接受首次手术治疗的1008例PMP临床数据库,比较卵巢转移组和卵巢未转移组之间的临床资料及预后差异。结果共入组164例患者,卵巢转移组113例,卵巢未转移组51例。中位随访28(1~131)个月,中位总生存(OS)期为51个月(95%CI为46.3~55.7个月),卵巢转移组为38个月(95%CI为33.7~42.3个月),卵巢未转移组未达到中位OS。5年OS率卵巢转移组为55.8%,卵巢未转移组为88%。Cox模型多因素预后分析显示肿瘤细胞减灭程度0/1,卵巢未转移和低级别病理学类型是良好OS的独立预后因素。结论对于阑尾源性PMP女性患者,卵巢转移是预后不良因素,推荐女性患者早期行细胞减灭术+腹腔热灌注化疗治疗。Objective Pseudomyxoma peritonei(PMP)is a clinically malignant tumor syndrome derived from mucinproducing appendiceal tumors.This study aimed to investigate the impact of ovarian metastasis on the long-term prognosis of female patients with appendiceal PMP.Methods We performed a retrospective analysis of 1008 patients with PMP undergoing primary surgery between 2008 and 2019 in Aerospace Center Hospital.The clinical data and prognosis were compared with ovarian metastases group and non-ovarian metastases group.Results Overall,164 patients were included in the study.There were 113 patients in the ovarian metastasis group and 51 patients in the non-ovarian metastasis group.Median followup was 28(1-131)months.The median overall survival(OS)was 51 months(95%CI:46.3-55.7)in thewhole group,38 months(95%CI:33.7-42.3)in ovarian metastases group and notachieved in non-ovarian metastases group.The 5-year OS rate was 55.8%in ovarian metastases group and 88%in non-ovarian metastases group.Multivariate survival analysis with Cox model showed that completeness of cytoreduction 0/1,non-ovarian metastases and low-grade pathological subtype were independent prognostic factors for good OS.Conclusions For female patients with appendiceal PMP,ovarian metastasis is a poor prognostic factor,and early cytoreductive surgery+hyperthermic intraperitoneal chemotherapyare recommended.

关 键 词：腹膜假黏液瘤 卵巢转移 细胞减灭术 腹腔热灌注化疗预后 

分 类 号：R735.36[医药卫生—肿瘤]