A rare complication of measles infection presented with subacute sclerosing panencephalitis: Report of two cases in India  

作　　者：Razeen Fatima Amir Husain Iram Tabish 

机构地区：[1]Department of Medicine,JN Medical College,AMU,Aligarh,India

出　　处：《Asian Pacific Journal of Tropical Medicine》2024年第4期184-187,共4页亚太热带医药杂志（英文版）

摘　　要：Rationale:Subacute sclerosing panencephalitis(SSPE)is a progressive neurological disorder caused by persistent measles virus infection.SSPE predominantly affects children and adolescents.The symptoms usually develop 6-15 years after measles infection and ultimately leading to death in many cases.Patient concerns:Patient 1 presented with cognitive decline and myoclonus and the Patient 2 presented with diminution of vision with myoclonic jerks.Diagnosis:Based on the clinical features with a characteristic electroencephalogram pattern and the presence of a high titer of anti-measles IgG in serum and cerebrospinal fluid,these patients were diagnosed as SSPE.Interventions:Antiepileptics were started for controlling myoclonus along with supportive treatment.Outcomes:Both patients were discharged on antiepileptics and supportive care.Lessons:Whenever there are unusual clinical manifestations with unknown vaccination status,SSPE can be suspected and the cerebrospinal fluid should be examined for anti-measles antibodies.Our case study also highlights the importance of universal coverage of measles vaccination.To reduce the incidence of measles and associated deaths,it is important to maintain a high level of immunization coverage for the measles vaccine and to strengthen all the integral components of the national immunization program.

关 键 词：Subacute sclerosing panencephalitis MEASLES MYOCLONUS ELECTROENCEPHALOGRAM Cerebrospinal fluid 

分 类 号：R741[医药卫生—神经病学与精神病学]