氨基质子转移成像对帕金森患者小脑微结构代谢变化的初步探究  

A preliminary study on the changes of cerebellar microstructure and metabolism in patients with Parkinson's frozen gait by amino proton transfer imaging

作　　者：聂聪科[1] 林威龙 马景旭[1] NIE Congke;LIN Weilong;MA Jingxu(Department of Medical Imaging,The Second Affiliated Hospital of Xinjiang Medical University,Urumqi 830028,China;Department of Medical Imaging,Tai'an Central Hospital,Tai'an 271000,China)

机构地区：[1]新疆医科大学第二附属医院医学影像科,新疆乌鲁木齐830028 [2]山东省泰安市中心医院医学影像科,山东泰安271000

出　　处：《医学影像学杂志》2024年第5期1-4,共4页Journal of Medical Imaging

基　　金：新疆维吾尔自治区自然科学基金资助项目(编号:2022D01C272)。

摘　　要：目的 探讨利用MR氨基质子转移成像(amide proton transfer,APT)和弥散张量成像(diffusion tensor image,DTI)对帕金森病(parkinson’s disease,PD)患者小脑微结构变化的临床应用价值。方法 选取我院46例PD患者为PD组进行APT和DTI检查,并选取48例健康者作为对照组。根据APT和DTI分别对感兴趣区测出MTR值和FA值,并分析组间差异。以t检验评估其参数对PD是否有一定诊断价值。结果 PD组小脑髓质的FA值和ADC值与对照组相比FA值减低,ADC值增高,差异有统计学意义(P<0.001);PD组齿状核FA值低于对照组,MTR值低于对照组,差异有统计学意义(P<0.001)。PD组黑质FA值低于对照组,MTR值低于对照组,差异有统计学意义(P<0.001)。在ROC分析中齿状核与黑质在MTR值对PD具有一定的诊断准确性(P<0.05),小脑髓质、齿状核与黑质FA值对PD具有一定的诊断准确性(P<0.05)。结论 APT可以反映PD患者小脑微结构代谢的变化,其参考值可以作为PD患者评估指标。Objective To investigate the clinical value of amino proton transfer(APT)and diffusion tensor image(DTI)in the changes of cerebellar microstructure in patients with Parkinson's disease(PD).Methods 46 patients with PD in our hospi⁃tal were selected for amino proton transfer imaging and diffusion tensor imaging,and 48 patients were selected as the control group.According to amino proton transfer imaging and diffusion tensor imaging,MTR and FA values of the region of interest were measured respectively,and the differences between groups were analyzed.T-test was used to evaluate whether its param⁃eters had certain diagnostic value for PD.Compared with results of the control group,the FA value and ADC value of cerebellar white matter in PD patients decreased,and the ADC value increased statistically(P<0.001);the FA value of dentate nucleus in PD patients was lower than that in the control group,and the MTR value was higher than that in the control group(P<0.001).Results Compared with the control group,the FA value and ADC value of cerebellar white matter in PD patients decreased,and the ADC value increased statistically(P<0.001);the FA value of dentate nucleus in PD patients was lower than that in the control group,and the MTR value was higher than that in the control group(P<0.001).In ROC analysis,the dentate nucleus and substantia nigra had certain diagnostic accuracy in PD patients(P<0.05),while the cerebellar medulla,dentate nucleus,and substantia nigra have certain diagnostic accuracy in FA for PD patients(P<0.05).Conclusion Amino proton transfer imaging can reflect the changes of cerebellar microstructure metabolism in patients with Parkinson's frozen gait,and its reference value can be used as an evaluation index for patients with PD.

关 键 词：帕金森病 小脑 齿状核 氨基质子转移成像 磁共振成像 

分 类 号：R742.5[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]