聚维酮碘含漱液结合盐酸米诺环素软膏在慢性牙周炎治疗中的疗效及安全性评价  

Efficacy and safety of povidone-iodine gargle combined with minocycline hydrochloride ointment in treatment of chronic

作　　者：杨煦[1] 徐文靖[1] 李洪发[2] Yang Xu;Xu Wen-jing;Li Hong-fa(Department of Stomatology,Tianjin Children’s Hospital/Tianjin University Children’s Hospital,Tianjin Institute of Pediatrics,Tianjin Key Laboratory for Prevention and Control of Birth Defects in Children,Tianjin 300074,China;Department of Orthodontics,Stomatological Hospital,Tianjin Medical University,Tianjin 300070,China)

机构地区：[1]天津市儿童医院(天津大学儿童医院,天津市儿科研究所,天津市儿童出生缺陷防治重点实验室)口腔科,天津300074 [2]天津医科大学口腔医院正畸科,天津300070

出　　处：《中国药物应用与监测》2024年第2期176-179,共4页Chinese Journal of Drug Application and Monitoring

基　　金：天津市医学重点学科(专科)建设项目(TJYXZDXK-040A)。

摘　　要：目的探讨聚维酮碘含漱液(PVP-I)结合盐酸米诺环素软膏在治疗慢性牙周炎方面的疗效及其安全性。方法选取自2019年8月—2022年3月在天津市儿童医院就诊的106例慢性牙周炎患者,根据随机数字表法将研究对象随机分为对照组和研究组。其中,对照组46例予以盐酸米诺环素软膏治疗,研究组60例另外加用PVP-I治疗。对比两组患者疗效及不良反应。结果研究组治疗后总有效率为95.0%,较对照组的78.3%高(χ^(2)=5.314,P=0.021);研究组治疗后口腔健康评分为(8.9±1.1)分,低于对照组的(16.8±2.0)分(t=25.928,P<0.001)。研究组治疗后牙周探诊深度(PD)、龈沟出血指数(SBI)、临床附着水平(CAL)、菌斑指数(PLI)分别为(2.1±0.2)mm、(1.1±0.1)、(2.6±0.2)mm、(1.8±0.2),均低于对照组的(3.8±0.4)mm、(2.4±0.2)、(3.2±0.3)mm、(2.8±0.3)(t=28.661,43.759,12.332,20.554,均P<0.001)。研究组治疗后不良反应发生率为3.4%,低于对照组为4.3%(χ^(2)=0.133,P=0.715)。结论使用PVP-I与盐酸米诺环素软膏的联合治疗方案在治疗慢性牙周炎方面展现出了突出的疗效,显著提升了患者的治疗效果和预后质量,且不增加用药风险,值得进一步大样本研究。Objective To assess the therapeutic efficacy and safety of a combination treatment consisting of minocycline hydrochloride ointment and PVP-I for patients suffering from chronic periodontitis.Methods A total of 106 patients with chronic periodontitis treated in Tianjin Children’s Hospital from August 2019 to March 2022 were enrolled and randomized into experimental group and control group.The 60 patients in the experimental group received therapy with both minocycline hydrochloride ointment and PVP-I.Concurrently,the 46 patients in the control one received treatment with minocycline hydrochloride ointment alone.Then the efficacy of the treatments in both groups was evaluated and compared.Results The combined response rate for the experimental group reached 95.0%,outperforming the 78.3% rate seen among the control participants.This variance was statistically notable(χ^(2)=5.314,P=0.021).After treatment,the experimental group displayed an oral health score of 8.9±1.1,which showed a substantial decrease from the control group’s score of 16.8±2.0(t=25.928,P<0.001).Furthermore,the experimental group showed improvements in various periodontal indices.The SBI,PD,CAL and PLI were all lower in the experimental group(1.1±0.1,2.1±0.2,2.6±0.2,1.8±0.2 mm,respectively)than those in the control[(2.4±0.2,3.8±0.4,3.2±0.3,2.8±0.3 mm,respectively)(t=28.661,43.759,12.332,20.554,all P<0.001)],confirming the statistical significance of the differences.Regarding adverse reactions,there was no notable discrepancy between the experimental group(3.4%)and the control(4.3%)(χ^(2)=0.133,P=0.715).Conclusion The use of minocycline hydrochloride ointment combined with PVP-I demonstrates enhanced effectiveness in the treatment of chronic periodontitis without an elevated risk of adverse reactions.It can remarkably improve the prognosis in patients,warranting further investigation of larger clinical samples.

关 键 词：盐酸米诺环素软膏 疗效 慢性牙周炎 聚维酮碘含漱液 安全性 

分 类 号：R781.42[医药卫生—口腔医学] R969.3[医药卫生—临床医学]