异甘草酸镁联合腺苷蛋氨酸治疗肝衰竭的效果及对氧化应激指标的影响  

Effect of magnesium isoglycyrrhizinate combined with ademetionine in the treatment of liver failure and its influences on oxidative stress indexes

作　　者：田艳茹 杨淑娟 TIAN Yanru;YANG Shujuan(Xi'an Eighth Hospital,Xi'an 710061,China)

机构地区：[1]西安市第八医院,陕西西安710061

出　　处：《临床医学研究与实践》2024年第16期80-83,共4页Clinical Research and Practice

基　　金：西安市科技计划项目[No.2019114613YX001SF035(13)]。

摘　　要：目的探讨异甘草酸镁联合腺苷蛋氨酸治疗肝衰竭的效果及对氧化应激指标的影响。方法选取2019年6月至2022年6月本院收治的100例肝衰竭患者作为研究对象,依据患者入院编号的奇偶性将其均分为对照组(奇数,50例)与观察组(偶数,50例)。对照组行常规方案治疗,观察组行异甘草酸镁联合腺苷蛋氨酸方案治疗。比较两组的治疗效果、肝功能指标、炎症指标及氧化应激指标。结果观察组的治疗总有效率高于对照组(P<0.05)。治疗后,观察组的总胆红素(TBIL)、谷丙转氨酶(ALT)及碱性磷酸酶(AKP)水平均低于对照组,白蛋白(ALB)水平高于对照组(P<0.05)。治疗后,观察组的白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)及C反应蛋白(CRP)水平均低于对照组,白细胞介素-10(IL-10)水平高于对照组(P<0.05)。治疗后,观察组的丙二醛(MDA)、血浆皮质醇(Cor)水平低于对照组,超氧化物歧化酶(SOD)、谷胱甘肽过氧化酶(GSH-Px)水平高于对照组(P<0.05)。结论异甘草酸镁联合腺苷蛋氨酸不但可以显著提升肝衰竭患者的治疗效果,还有助于减轻炎症及氧化应激损伤,促进患者肝功能恢复。Objective To investigate the effect of magnesium isoglycyrrhizinate combined with ademetionine in the treatment of liver failure and its influences on oxidative stress indexes.Methods A total of 100 patients with liver failure admitted in our hospital from June 2019 to June 2022 were selected as the research objects.According to the parity of the patients'admission number,they were divided into control group(odd number,50 cases)and observation group(even number,50 cases).The control group was treated with conventional regimen,and the observation group was treated with magnesium isoglycyrrhizinate combined with ademetionine regimen.The therapeutic effect,liver function indexes,inflammation indexes and oxidative stress indexes were compared between the two groups.Results The total effective rate of treatment in the observation group was higher than that in the control group(P<0.05).After treatment,the levels of total bilirubin(TBIL),alanine aminotransferase(ALT)and alkaline phosphatase(AKP)in the observation group were lower than those in the control group,and the level of albumin(ALB)was higher than that in the control group(P<0.05).After treatment,the levels of interleukin-6(IL-6),tumor necrosis factor-α(TNF-α)and C-reactive protein(CRP)in the observation group were lower than those in the control group,and the level of interleukin-10(IL-10)was higher than that in the control group(P<0.05).After treatment,the levels of malondialdehyde(MDA)and plasma cortisol(Cor)in the observation group were lower than those in the control group,and the levels of superoxide dismutase(SOD)and glutathione peroxidase(GSH-Px)were higher than those in the control group(P<0.05).Conclusion Magnesium isoglycyrrhizinate combined with ademetionine can not only significantly improve the therapeutic effect of patients with liver failure,but also help to reduce inflammation and oxidative stress damage and promote the recovery of liver function of patients.

关 键 词：异甘草酸镁 腺苷蛋氨酸 肝衰竭 氧化应激 

分 类 号：R575.3[医药卫生—消化系统]