O连接N-乙酰葡萄糖胺糖基化修饰在神经退行性疾病中的研究进展  

Research Progress on O-GLcNAc Glycosylation Modification in Neurodegenerative Diseases

作　　者：余婷 刘海军 YU Ting;LIU Haijun(Department of Neurology,Affiliated Hospital of Zunyi Medical University,Zunyi 563000,China;Graduate School of Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]遵义医科大学附属医院神经内科,贵州遵义563000 [2]遵义医科大学研究生院,贵州遵义563000

出　　处：《中山大学学报（医学科学版）》2024年第3期370-376,共7页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：贵州省科技厅科技支撑计划项目(黔科合支撑[2020]4Y144号);贵州省卫生和计划生育委员会科学技术基金项目(gzwjkj2018-1-001);遵义医科大学“12345”未来人才培养计划“未来临床名医”项目(20211004)。

摘　　要：O连接N-乙酰葡萄糖胺(O-GlcNAc)糖基化是一种由O-键连接的乙酰氨基葡萄糖和胞内蛋白上的丝氨酸/苏氨酸残基形成的蛋白质翻译后修饰。O-GlcNAc糖基化修饰在脑内普遍存在,其与转录、翻译和蛋白稳态等关系密切。O-GlcNAc糖基化修饰参与多种神经系统变性疾病的发生发展,但其调控机制尚不清楚。现就O-GlcNAc糖基化修饰与神经系统退行性病变的关系作一综述。O-linked N-acetylglucosamine glycosylation(O-GlcNAcylation)is a protein post-translational protein formed by O-linked acetylglucosamine and serine/threonine residues on intracellular proteins.O-GlcNAc glycosylation modification is ubiquitous in the brain and is closely related to transcription,translation and protein homeostasis.O-GlcNAc glycosylation modification is involved in the occurrence and development of various neurological degenerative dis-eases,but its regulatory mechanism remains unclear.This paper reviews the relationship between O-GlcNAc glycosylation modification and neurological degenerative diseases.

关 键 词：O连接N-乙酰葡萄糖胺糖基化 神经退行性变 O连接N-乙酰葡萄糖胺糖基转移酶 O连接N-乙酰葡萄糖胺糖苷酶 糖基化修饰 

分 类 号：R749.1[医药卫生—神经病学与精神病学]