伴有童年创伤的重症抑郁患者异常全脑功能连接:一项静息态功能磁共振研究  

Abnormal Global Brain Functional Connectivity in MDD Patients with Childhood Trauma:A Resting-State fMRI Study

作　　者：吴草军 傅世舜 江桂华[2] 马晓芬[2] 田军章 WU Caojun;FU Shishun;JIANG Guihua;MA Xiaofen;TIAN Junzhang(The Second School of Clinical Medicine,Southern Medical University,Guangzhou,510280,China;Department of Medical Imaging,Guangdong Second Provincial General Hospital,Guangzhou,510317,China)

机构地区：[1]南方医科大学第二临床医学院,广东广州510280 [2]广东省第二人民医院影像科,广东广州510317

出　　处：《中山大学学报（医学科学版）》2024年第3期420-428,共9页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：国家自然科学基金(82001792)。

摘　　要：【目的】童年创伤(CT)被认为是成年后发展为重度抑郁(MDD)的主要危险因素之一。然而,伴有CT的MDD(CT-MDD)患者的神经基础仍然知之甚少。因此,本研究的目的是探讨CT-MDD患者静息态全脑功能连接(FC)。【方法】对34名CT-MDD患者和34名健康对照组进行静息态功能磁共振扫描。进行全脑体素水平度中心性(DC)分析,选取两组间显著差异的脑区作为感兴趣区(ROI),进一步计算全脑FC。随后,将异常脑区DC,FC值与临床量表进行相关性分析。【结果】CT-MDD组右侧额中回(MFG)的DC值高于健康对照组。基于种子点的脑功能连接分析发现,与健康对照组相比,CT-MDD组右侧MFG与右内侧前额叶和左侧楔前叶之间的FC增加(P<0.05)。此外,右侧MFG的DC值与CT严重程度相关。【结论】我们的结果表明,以右侧MFG作为ROI,其与默认网络(DMN)中的两个重要脑区右内侧前额叶和左侧楔前叶之间的FC增加,这可能表明CT-MDD患者的认知执行网络与DMN之间的同步性增加。这些发现可能为深入了解CT-MDD的病理生理机制提供了见解。【Objective】Childhood trauma(CT)is considered one of the major risk factors for developing major depressive disorder(MDD)in adulthood.However,the neural basis of MDD patients with CT(CT-MDD)remains poorly understood.Therefore,the objective of our study is to explore the resting-state global brain functional connectivity(FC)in CT-MDD.【Methods】A total of 34 CT-MDD and 34 healthy controls performed resting-state fMRI.Whole-brain voxel-level degree centrality(DC)analysis was performed,and the brain regions with significant differences between the two groups were selected as region of interest(ROI)for further estimating the global brain FC.Subsequently,correlation analysis was performed between DC values,FC values in abnormal brain areas and clinical characteristics.【Results】The CT-MDD group showed increased DC value of the right middle frontal gyrus(MFG)compared with the healthy controls.Seed-based FC revealed that the CT-MDD group showed increased connections between the left precuneus and the right MFG or the right medial prefrontal cortex,relative to healthy controls(threshold at P<0.05).Additionally,the DC value of the right MFG was correlated with the severity of CT.【Conclusion】Our results show the increased FC between the left precuneus and the ROI(right MFG)as well as the right medial prefrontal cortex,which are two important brain regions within the default mode network(DMN),and might suggest increased synchronism between the cognitive executive networks and DMN in CT-MDD.These findings may provide insights into the pathophysiological mechanisms underlying CT-MDD.

关 键 词：童年创伤 重症抑郁 度中心性 功能连接 默认网络 

分 类 号：R749.4[医药卫生—神经病学与精神病学]