氨磺必利联合重复经颅磁刺激治疗对精神分裂症后抑郁伴自杀倾向患者社会功能及心理健康的影响  

Effects of Amisulpride Combined with Repetitive Transcranial Magnetic Stimulation Therapy on Social Functioning and Mental Health in Patients with Post-schizophrenic Depression with Suicidal Tendencies

作　　者：张小娟 陈正 ZHANG Xiaojuan;CHEN Zheng(Department of Psychiatry,Lanzhou Third People's Hospital,Lanzhou,Gansu Province,730050 China;Department of Psychiatry,Shanghai Mental Health Center,Shanghai,200030 China)

机构地区：[1]兰州市第三人民医院精神科,甘肃兰州730050 [2]上海市精神卫生中心精神科,上海200030

出　　处：《系统医学》2024年第7期23-27,共5页Systems Medicine

基　　金：兰州市科技计划项目(2021-ZD-024)。

摘　　要：目的分析针对精神分裂症后抑郁伴自杀倾向患者,应用氨磺必利联合重复经颅磁刺激治疗对其社会功能及心理健康的影响。方法本研究选取2021年12月—2023年10月兰州市第三人民医院收治的120例精神分裂症后抑郁伴自杀倾向患者为研究对象,根据治疗方式的不同分为常规组(n=60)和联合组(n=60),常规组接受氨磺必利常规治疗,联合组在常规组基础上联合重复经颅磁刺激治疗,对比两组患者的心理健康状态、认知功能和社会功能、临床疗效和不良反应发生情况。结果治疗前,两组患者的症状自评量表(Symptom Check List-90,SCL-90)评分对比,差异无统计学意义(P>0.05);治疗后,两组的SCL-90评分均有所下降,且联合组低于常规组,差异有统计学意义(P<0.05);治疗前,两组患者的精神分裂症认知功能成套测验共识版(Matrics Consensus Cognitive Battery,MCCB)评分和个人与社会表现量表(Personal and Social Performance Scale,PSP)评分对比,差异无统计学意义(P均>0.05);治疗后,两组MCCB评分和PSP评分均有所上升,且联合组高于常规组,差异有统计学意义(P均<0.05);联合组患者的治疗有效率为95.00%,高于常规组患者的83.33%,差异有统计学意义(P<0.05);联合组患者的不良反应发生率为8.33%,低于常规组患者的15.00%,差异无统计学意义(P>0.05)。结论针对精神分裂症后抑郁伴自杀倾向患者,应用氨磺必利联合重复经颅磁刺激治疗效果确切,对患者认知功能、社会功能及心理健康的恢复具有积极作用,且安全性高。Objective To analyze the effects of the application of amisulpride combined with repetitive transcranial magnetic stimulation treatment on social functioning and mental health in patients with post-schizophrenic depression with suicidal tendency.Methods A total of 120 patients with post-schizophrenia depression with suicidal tendency who were admitted to Lanzhou Third People's Hospital from December 2021 to October 2023 were selected as the study objects and divided into the conventional group(n=60)and the combined group(n=60)according to the different treatment modalities.Patients in the conventional group received amisulpride conventional treatment,and patients in the combined group were combined with repetitive transcranial magnetic stimulation treatment on the basis of the conventional group.The mental health status,cognitive and social functions,clinical efficacy and occurrence of adverse reactions of patients in the two groups were compared.Results Before treatment,there were no statistically significant difference in the Symptom Check List-90(SCL-90)scores of the two groups(P>0.05).After treatment,the SCL-90 scores in both groups decreased,and the combined group were lower than those in the conventional group,and the difference was statistically significant(P<0.05).Before treatment,the Matrics Consensus Cognitive Battery(MCCB)scores and Personal and Social Performance Scale(PSP)scores of the patients in the two groups were not statistically significant differences(both P>0.05).After treatment,the MCCB scores and PSP scores in both groups increased,and the combined group were higher than those in the conventional group,and the differences were statistically significant(both P<0.05).The therapeutic efficiency of patients in the combined group was 95.00%,which was higher than that of patients in the conventional group(83.33%),and the difference was statistically significant(P<0.05).The incidence rate of adverse reactions of patients in the combined group was 8.33%,lower than that of patients in the convention

关 键 词：精神分裂症 抑郁伴自杀倾向 氨磺必利 重复经颅磁刺激治疗 

分 类 号：R749.3[医药卫生—神经病学与精神病学]