血清L/A、NRG-1、Tie-2水平与首发精神分裂症患者临床症状严重程度的相关性  

Correlation between Serum L/A,NRG-1,Tie-2 Levels and the Severity of Clinical Symptoms in Patients with First-episode Schizophrenia

作　　者：戴璐 任学娟[3] 殷旭园 DAI Lu;REN Xuejuan;YIN Xuyuan(Department of Clinical Laboratory,the Affiliated Guangji Hospital of Soochow University,Suzhou,Jiangsu 215137,China;Department of Encephalopathy,Kunshan Hospital of Traditional Chinese medicine,Kunshan,Jiangsu 215300,China;Institute of Mental Health,the Affiliated Guangji Hospital of Soochow University,Suzhou,Jiangsu 215137,China)

机构地区：[1]苏州大学附属广济医院临床检验科,苏州江苏215137 [2]苏州大学附属广济医院中心实验室,苏州江苏215137 [3]昆山市中医医院脑病科,江苏昆山215300

出　　处：《临床误诊误治》2024年第7期60-66,共7页Clinical Misdiagnosis & Mistherapy

基　　金：苏州市科技局医学创新应用研究(SKYD2022146);昆山市科技专项社会发展项目(KSF202138)。

摘　　要：目的探讨血清瘦素与脂联素比值(L/A)、神经调节蛋白-1(NRG-1)、血管生成素受体酪氨酸激酶-2(Tie-2)水平与首发精神分裂症患者临床症状严重程度的相关性及对认知障碍的评估价值。方法选择2021年5月—2023年5月收治的首发精神分裂症103例为研究组,另选取同期正常健康体检志愿者103例为对照组。比较2组血清L/A、NRG-1、Tie-2水平,对比研究组认知障碍与认知正常患者临床症状[阳性和阴性症状量表(PANSS)、简明精神病评定量表(BPRS)评分]、血清L/A、NRG-1、Tie-2水平。分析血清L/A、NRG-1、Tie-2水平与临床症状严重程度的相关性及其联合检测对认知障碍的评估价值。结果研究组血清瘦素、L/A水平高于对照组,脂联素、NRG-1、Tie-2水平低于对照组(P<0.01)。研究组认知障碍患者PANSS各分量表评分及总分、BPRS量表各维度评分及总分、血清瘦素、L/A水平高于认知正常患者,脂联素、NRG-1、Tie-2水平低于认知正常患者(P<0.01)。血清L/A水平与PANSS各分量表评分及总分、BPRS量表各维度评分及总分呈正相关,NRG-1、Tie-2水平与PANSS各分量表评分及总分、BPRS量表各维度评分及总分呈负相关(P<0.01)。血清L/A、NRG-1、Tie-2评估认知障碍的曲线下面积(AUC)分别为0.764、0.708、0.755,最佳截断值分别为6.81、8.52 pg/mL、1962.62 pg/mL;血清L/A高表达、NRG-1、Tie-2低表达分别提示认知障碍发生风险增加5.237、6.172、4.538倍;L/A、NRG-1、Tie-2两两联合及三者联合评估认知障碍的AUC分别为0.882、0.868、0.876、0.932。结论血清L/A、NRG-1、Tie-2与首发精神分裂症患者临床症状严重程度显著相关,异常表达增加认知障碍发生风险,联合评估认知障碍的价值更为可靠。Objective To investigate the correlation of serum leptin(LEP)to adiponectin ratio(L/A),neuregulin-1(NRG-1),angiopoietin receptor tyrosine kinase 2(Tie-2)levels with the severity of clinical symptoms and their value in evaluation of cognitive dysfunction in patients with first-episode schizophrenia.Methods A total of 103 patients with first-episode schizophrenia admitted from May 2021 to May 2023 were selected as the research group,and 103 normal healthy volunteers undergoing physical examination during the same period were selected as the control group.Serum levels of L/A,NRG-1 and Tie-2 were compared between the two groups,and clinical symptoms[Positive and Negative Symptom Scale(PANSS),Brief Psychiatric Rating Scale(BPRS)scores],serum levels of L/A,NRG-1 and Tie-2 were compared between patients with cognitive dysfunction and normal cognitive function in the research group.The correlation between serum L/A,NRG-1,Tie-2 levels and the severity of clinical symptoms and the value of combined detection in the evaluation of cognitive dysfunction were analyzed.Results The levels of leptin and L/A in the research group were higher than those in the control group,while the levels of adiponectin,NRG-1 and Tie-2 in the research group were lower than those in the control group(P<0.01).In the research group,the scores and total scores of PANSS subscales,the scores and total scores of BPRS scales,and the levels of leptin and L/A in patients with cognitive dysfunction were higher than those in patients with normal cognitive function,while the levels of adiponectin,NRG-1 and Tie 2 levels were lower than those in patients with normal cognitive function(P<0.01).Serum L/A level was positively correlated with the score and total score of PANSS subscales and the score and total score of BPRS scale,while NRG-1 and Tie-2 levels were negatively correlated with the score and total score of PANSS subscale and total score of BPRS scale(P<0.01).The area under the receiver operating characteristic(ROC)curve(AUC)of serum L/A,NRG-1 and Tie-2

关 键 词：精神分裂症 认知障碍 瘦素 脂联素 神经调节蛋白-1 血管生成素受体酪氨酸激酶-2 阳性和阴性症状量表 简明精神病评定量表 

分 类 号：R749.3[医药卫生—神经病学与精神病学]