盐酸安非他酮联合盐酸舍曲林对青少年抑郁症疲劳感的治疗效果  

Efficacy of bupropion hydrochloride and sertraline hydrochloride in the treatmentof adolescent depression fatigue

作　　者：杜晖 戴立磊 陈佳悦 何欣芙 张伟 舒婧 阳广杰 DU Hui;DAI Lilei;CHEN Jiayue;HE Xinfu;ZHANG Wei;SHU Jing;YANG Guangjie(Department of Clinical Psychology,Jingmen People's Hospital,Jingmen 448000,China;Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine)

机构地区：[1]湖北省荆门市人民医院临床心理科,448000 [2]上海交通大学医学院附属精神卫生中心

出　　处：《中国健康心理学杂志》2024年第6期801-806,共6页China Journal of Health Psychology

基　　金：湖北省重点研发计划项目(编号:2022BCE032);荆门市科学技术研究与开发项目(编号:2021YFYB044,2022YDKY024)。

摘　　要：目的:探讨盐酸安非他酮联合盐酸舍曲林对青少年抑郁症疲劳感的治疗效果。方法:于2021年6月至2023年5月收集100例青少年抑郁症患者进行研究,随机分为研究组与对照组各50例,两组患者均采用盐酸舍曲林治疗,研究组在盐酸舍曲林基础上联合盐酸安非他酮治疗,治疗前及治疗2周、4周后采用患者健康问卷抑郁症状群量表(PHQ-9)、广泛性焦虑障碍量表(GAD-7)、疲劳量表(FS-14)进行心理评估,明确治疗效果。结果:①两组患者治疗前PHQ-9、GAD-7评分比较差异均无统计学意义(P>0.05),治疗2周、4周后研究组的PHQ-9评分比对照组降低的更明显,重复测量方差分析显示治疗后两组PHQ-9评分的时间效应、组间效应及交互效应均显著(F_(时间)=447.956,F_(组间)=4.305,F_(交互)=30.358;P<0.05);两组患者GAD-7评分的在治疗2周及4周后均明显降低,重复测量方差分析显示治疗后两组GAD-7评分的时间效应显著(F_(时间)=229.364,P<0.05),组间效应及交互效应无差异(P>0.05);②两组患者治疗前FS-14评分比较差异均无统计学意义(P>0.05),治疗2周、4周后研究组的FS-14评分比对照组降低的更明显,重复测量方差分析显示治疗后两组FS-14评分的时间效应、组间效应及交互效应均显著(F_(时间)=784.133,F_(组间)=149.191,F_(交互)=66.486;P<0.01);③两组患者治疗前每日平均卧床时间比较差异无统计学意义(P>0.05);治疗2周后研究组每日平均卧床时间明显短于对照组,两组比较差异有显著的统计学意义(P<0.01);治疗4周后两组比较差异无统计学意义(P>0.05);重复测量方差分析显示治疗后两组每日平均卧床时间的时间效应、组间效应及交互效应均显著(F_(时间)=319.977,F_(组间)=5.965,F_(交互)=6.929;P<0.05);④研究组的坐立不安、激越的发生率明显高于对照组,两组比较差异有统计学意义(χ^(2)=6.462,4.914;P<0.05)。结论:盐酸安非他酮联合盐酸舍曲林可以改善青Objective:To explore the therapeutic effect of bupropion hydrochloride and sertraline hydrochloride in the treatment of adolescent depression fatigue.Methods:A total of 100 adolescent depression patients was collected from June 2021 to May 2023,randomly divided into 50 cases in study group and control group.Both patients were treated with sertraline hydrochloride,and the study group combined bupropion hydrochloride based on sertraline hydrochloride,and evaluated PHQ-9,GAD-7 and FS-14 before and 2 weeks after treatment to determine the treatment effect.Results:①There was no significant difference in the PHQ-9 and GAD-7 scores between the two groups before treatment(P>0.05).After 2 weeks and 4 weeks of treatment,the PHQ-9 scores in the study group decreased more significantly than those in the control group.Repeated measures analysis of variance showed that the time effect,between-group effect,and interaction effect of the PHQ-9 scores in the two groups after treatment were significant(F_(time)=447.956,F_(between-groups)=4.305,F_(interaction)=30.358;P<0.05).The GAD-7 scores in both groups decreased significantly after 2 weeks and 4 weeks of treatment.Repeated measures analysis of variance showed that the time effect of the GAD-7 scores in the two groups after treatment was significant(F_(time)=229.364,P<0.05),while there was no difference in the between-group effect and interaction effect(P>0.05).②There was no significant difference in FS-14 scores between the two groups before treatment(P>0.05).After 2 weeks and 4 weeks of treatment,the FS-14 scores in the study group decreased more significantly than those in the control group.Repeated measures analysis of variance showed that the time effect,between-group effect,and interaction effect of FS-14 scores were significant in both groups after treatment(F_(time)=784.133,F_(between-groups)=149.191,F_(interaction)=66.486;P<0.01).③There was no significant difference in the average daily bedtime before treatment between the two groups(P>0.05).After 2 weeks of treatm

关 键 词：青少年 抑郁症 盐酸安非他酮 盐酸舍曲林 疲乏感 

分 类 号：R749.05[医药卫生—神经病学与精神病学] R395.4[医药卫生—临床医学]