辅助性T细胞9/白细胞介素⁃9在消化系统恶性肿瘤中的研究进展  

Research Progress of Helper T Cell 9/Interleukin⁃9 in Digestive System Cancers

作　　者：顾烨 陈卫昌[1] GU Ye;CHEN Weichang(Department of Gastroenterology,the First Affiliated Hospital of Soochow University,Suzhou,Jiangsu Province,215006)

机构地区：[1]苏州大学附属第一医院消化内科,215006

出　　处：《胃肠病学》2023年第9期551-555,共5页Chinese Journal of Gastroenterology

摘　　要：辅助性T细胞9(Th9)主要分泌白细胞介素⁃9(IL⁃9),在自身免疫病、寄生虫感染和变态反应性疾病中发挥重要作用。Th9/IL⁃9也参与了肿瘤免疫应答,尤其在实体肿瘤中,Th9/IL⁃9表现出强大的抗肿瘤特性,但在消化系统恶性肿瘤发生、发展中的作用尚不清楚。本文主要就Th9/IL⁃9的分化调控机制、生物学特性,以及在消化系统恶性肿瘤中的研究进展作一综述,以期为Th9应用于肿瘤免疫治疗提供有价值的依据。Helper T cell 9(Th9)predominantly secretes interleukin⁃9(IL⁃9),exerting pivotal roles in autoimmune diseases,parasitic infections,and allergic conditions.Furthermore,Th9/IL⁃9 have been found to be involved in tumor immune responses,especially in solid tumors.While Th9/IL⁃9 demonstrate potent anti⁃tumor properties,their implication in the pathogenesis of digestive system malignancies remains elusive.This article reviewed the regulatory mechanisms of Th9/IL⁃9 differentiation,biological characteristics and research progress in digestive system malignancies,in order to provide a valuable theoretical basis for the potential application of Th9 in tumor immunotherapy.

关 键 词：辅助性T细胞9 白细胞介素9 消化系统肿瘤 免疫疗法 

分 类 号：R735[医药卫生—肿瘤]