促牙本质再矿化树脂粘接材料提高牙本质粘接耐久性的研究进展  

Research progress of dentin remineralization promoting resin bonding materials to improve the durability of dentin bonding

作　　者：苗瑞婧 张存宝[1] 张黄[1] 王永 MIAO Rui-jing;ZHANG Cun-bao;ZHANG Huang;WANG Yong-wu(Department of Stomotology,Hangzhou First People’s Hospital,Hangzhou 310000,China)

机构地区：[1]武杭州市第一人民医院口腔科,杭州市第一人民医院,杭州310000

出　　处：《口腔颌面修复学杂志》2024年第3期234-240,共7页Chinese Journal of Prosthodontics

基　　金：杭州市卫生科技计划项目(项目编号:A20200072);浙江中医药大学教育教学改革研究项目(国际教育专项)(项目编号:GJ22006)。

摘　　要：促进牙本质再矿化是提高树脂-牙本质粘接耐久性的重要方法,国内国际有很多关于改性树脂粘接剂的研究,均致力于诱导混合层裸露牙本质胶原的再矿化。本文针对树脂-牙本质粘接面的耐久性问题,阐述了促牙本质再矿化树脂粘接材料的研究进展。促牙本质再矿化树脂粘接材料的改性策略包括:生物活性无机微填料策略,即以硅酸盐、磷酸钙盐和生物活性玻璃等无机材料为矿化离子来源诱导牙本质再矿化;仿生再矿化策略,即应用仿生类似物模拟非胶原蛋白(non-collagenous proteins,NCPs)的功能,引导矿物前驱体在特定位点矿化以获得与生物矿化类似的有序晶体沉积;以及锌添加剂保护胶原蛋白、介孔硅材料作为矿物离子输送系统的改性策略。Promoting remineralization of dentin is an important method to improve the bonding performance of resin bonding materials.There are many researches on modified resin bonding materials worldwide,all of which are committed to inducing remineralization of the mixed layer of exposed dentin collagen.Aiming at the durability of resin dentin bonding surface,this paper reviewed the research progress of resin modification strategies for remineralizing dentin.The modification strategies of the resin modified materials for dentin remineralization include:bioactive inorganic micro filler strategy,which uses inorganic materials such as silicate,calcium phosphate and bioactive glass as the source of mineralized ions to induce dentin remineralization;biomimetic remineralization strategy,that is,using biomimetic analogues to simulate the function of non collagenous proteins(NCPs),to guide mineral precursors to mineralize at specific sites to obtain ordered crystal deposits similar to biomineralization;zinc additives protect collagen and mesoporous silica as the modification strategy of mineral ion transport system.

关 键 词：树脂粘接材料 牙本质粘接 牙本质再矿化 

分 类 号：R783.1[医药卫生—口腔医学]