癫痫患儿认知功能、细胞凋亡因子的变化及其相关性分析  

Changes and correlation analysis of cognitive function and apoptosis factors in children with epilepsy

作　　者：马丽媛 蒲荣 王文海 MA Liyuan;PU Rong;WANG Wenhai(Department of Neurology,Qinghai Women and Children's Hospital,Xining 810000,Qinghai,China)

机构地区：[1]青海省妇女儿童医院神经内科,青海西宁810000

出　　处：《中南医学科学杂志》2024年第3期415-417,共3页Medical Science Journal of Central South China

基　　金：青海省指导性计划课题(2021-wjzdx-94)。

摘　　要：目的研究癫痫患儿认知功能、细胞凋亡因子的变化及其相关性分析。方法选择癫痫患儿150例为癫痫组,根据脑电图异常情况分为轻度组和重度组;另选取同期健康志愿者150例为对照组。比较各组认知功能言语智商、操作智商及总智商评分,以及细胞凋亡因子X连锁凋亡抑制蛋白(XIAP)、促凋亡基因(Bim)、Bcl-2关联X蛋白(Bax)、Caspase-3、Caspase-4、Caspase-9水平。分析细胞凋亡因子与认知功能的相关性。结果分别与对照组、轻度组比较,癫痫组、重度组言语智商、操作智商及总智商评分、XIAP降低,Bim、Bax、Caspase-3、Caspase-4、Caspase-9升高(P<0.05)。患儿言语智商、操作智商、总智商评分均与Bim、Bax、Caspase-3、Caspase-4、Caspase-9水平呈正相关,与XIAP呈负相关(P<0.05)。结论癫痫患儿细胞凋亡因子水平随脑电图异常加重而变化,可作为机体认知功能预测的重要依据。Aim To study the changes and correlation of cognitive function and apoptosis factors in children with epilepsy.Methods A total of 150 children with epilepsy were selected as the epilepsy group,and were further divided into a mild group and a severe group based on the abnormality of their electroencephalograms.Meanwhile,another 150 healthy volunteers were selected as the control group.The scores of verbal intelligence quotient,performance intelligence quotient,and full-scale intelligence quotient,as well as the levels of apoptotic factors,including X-linked inhibitor of apoptosis protein(XIAP),pro-apoptotic gene Bim,Bcl-2-associated X protein(Bax),Caspase-3,Caspase-4,and Caspase-9,were compared among the groups.The correlation between apoptotic factors and cognitive function was analyzed.Results Compared with the control group and the mild group,the epilepsy group and the severe group showed decreased scores in verbal intelligence quotient,performance intelligence quotient,and full-scale intelligence quotient,as well as decreased levels of XIAP,and increased levels of Bim,Bax,Caspase-3,Caspase-4,and Caspase-9(P<0.05).The children's VIQ,PIQ,and FSIQ scores were positively correlated with the levels of Bim,Bax,Caspase-3,Caspase-4,and Caspase-9,and negatively correlated with XIAP(P<0.05).Conclusion The levels of apoptotic factors in children with epilepsy were changed with the severity of electroencephalograms abnormalities and can serve as an important basis for predicting cognitive function.

关 键 词：细胞凋亡因子 癫痫 认知功能 

分 类 号：R742.1[医药卫生—神经病学与精神病学]