膀胱癌组织中葡萄糖转运蛋白-4、连接蛋白-4的表达及其与临床病理特征及预后的关系研究  

Expression of GLUT4 and nectin-4 in bladder cancer and their relationship with clinicopathological characteristics and prognosis

作　　者：肖永强 李超 王亚轩[2] 李永召 XIAO Yong-qiang;LI Chao;WANG Ya-xuan(Department of Urology,Shijiazhuang People's Hospital,Shijiazhuang(050000),China)

机构地区：[1]石家庄市人民医院泌尿外科,河北石家庄050000 [2]河北医科大学第二医院泌尿外科,河北石家庄050004 [3]石家庄市人民医院重症肌无力中心,河北石家庄050000

出　　处：《中国中西医结合外科杂志》2024年第3期319-323,共5页Chinese Journal of Surgery of Integrated Traditional and Western Medicine

基　　金：石家庄市科学技术研究与发展指导计划(161460693)。

摘　　要：目的:探讨膀胱癌组织中葡萄糖转运蛋白-4(GLUT4)、连接蛋白-4(nectin-4)的表达及其与临床病理特征及预后的关系。方法:收集本院2018年5月—2021年8月间治疗的90例膀胱癌患者癌组织石蜡标本及其对应的癌旁正常组织石蜡标本。对比膀胱癌组织与癌旁组织中GLUT4、nectin-4的阳性表达率,分析GLUT4、nectin-4的表达与临床病理特征及预后的关系,采用COX回归模型分析患者预后的影响因素。结果:GLUT4、nectin-4在膀胱癌组织中的阳性率分别为75.56%与80.00%,高于GLUT4、nectin-4在癌旁正常组织中的阳性率(25.56%与31.11%),差异有统计学意义(P<0.05);GLUT4在膀胱癌组织中的表达情况与病理分级、临床分期及淋巴结转移有关(P<0.05);nectin-4在膀胱癌组织中的表达情况与肿瘤最大直径、病理分级、临床分期及淋巴结转移有关(P<0.05);随访至2023年10月,膀胱癌组织中GLUT4、nectin-4阳性表达患者无病中位生存时间32.52个月与34.18个月,均高于GLUT4、nectin-4阴性表达患者(26.25个月与27.47个月)(P<0.05);COX多因素回归分析结果显示,临床分期(肌层浸润)、淋巴结转移(有)、GLUT4(阳性表达)与nectin-4(阳性表达)为影响膀胱癌患者预后的独立危险因素(P<0.05)。结论:GLUT4、nectin-4在膀胱癌组织中均具有高表达,两项指标与膀胱癌患者病情发展及预后密切相关,为影响患者预后的独立危险因素。Objective To investigate the expression of glucose transporter-4(GLUT4)and nectin-4 in bladder cancer and their relationship with clinicopathological characteristics and prognosis.Methods The paraffin samples of 90 bladder cancer patients and their corresponding paracancerous normal tissues treated in our hospital from May 2018 to August 2021 were collected as research objects.To compare the positive expression rate of GLUT4 and nectin-4 in bladder cancer tissues and adjacent tissues,analyze the relationship between the expression of GLUT4 and nectin-4 and clinicopathological characteristics and prognosis,and analyze the influencing factors of patients'prognosis with COX regression model.Results The positive rates of GLUT4 and nectin-4 in bladder cancer tissues were 75.56%and 80.00%respectively,which were higher than those of GLUT4 and nectin-4 in normal adjacent tissues(25.56%and 31.11%,P<0.05).The expression of GLUT4 in bladder cancer was related to pathological grade,clinical stage and lymph node metastasis(P<0.05).The expression of nectin-4 in bladder cancer tissue was related to the maximum tumor size,pathological grade,clinical stage and lymph node metastasis(P<0.05);During the follow-up to October 2023,the median disease-free survival time of patients with positive expression of GLUT4 and nectin-4 in bladder cancer tissue was 32.52 months and 34.18 months,which were higher than those of patients with negative expression of GLUT4 and nectin-4(26.25 months and 27.47 months,P<0.05);COX multivariate regression analysis showed that clinical stage(muscle invasion),lymph node metastasis(presence),GLUT4(positive expression)and connectin-4(positive expression)were independent risk factors affecting the prognosis of bladder cancer patients(P<0.05).Conclusion Both GLUT4 and nectin-4 are highly expressed in bladder cancer tissue.These two indicators are closely related to the development and prognosis of bladder cancer patients,and are independent risk factors affecting the prognosis of patients.

关 键 词：葡萄糖转运蛋白-4 连接蛋白-4 膀胱癌 病理特征 预后 相关性 

分 类 号：R737.1[医药卫生—肿瘤]