5.0T全脑准连续动脉自旋标记MRI参数优化  

Optimization for parameters of 5.0T pseudo continuous arterial spin labeling MRI of whole brain

作　　者：李冬雪 范晓媛 韩华璐 陈硕 孙伟 有慧 李明利 冯逢 LI Dongxue;FAN Xiaoyuan;HAN Hualu;CHEN Shuo;SUN Wei;YOU Hui;LI Mingli;FENG Feng(Department of Radiology,Translation Medicine Center,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China;United Imaging Healthcare,Shanghai 201807,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院协和转化医学中心放射科,北京100730 [2]上海联影医疗科技股份有限公司,上海201807

出　　处：《中国医学影像技术》2024年第5期643-647,共5页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金面上项目(82071899、82371946)、中国医学科学院医学与健康科技创新工程(2021-I2M-1-025)、北京市自然科学基金(7222131)。

摘　　要：目的探讨5.0T全脑准连续动脉自旋标记(pCASL)MRI参数优化。方法前瞻性招募9名健康成人,利用5.0T MR仪行单延迟pCASL扫描,设置3组标记梯度:A组,平均梯度(G_(avg))=1 mT/m,最大梯度(G_(max))与G_(avg)比值(G_(ratio))=10;B组,G_(avg)=0.6 mT/m,G_(ratio)=10;C组,G_(avg)=0.3 mT/m,G_(ratio)=9。比较3组标记效率及脑血流量(CBF);筛选最佳标记梯度组。结果标记血流平均速度为40 cm/s、B1+降低和B0偏移频率较大时,C组梯度场容纳度优于A、B组。C组梯度场下,标记动脉B1水平为54.19%~75.36%、平均64.71%;该组标记效率均≥85%平均B1水平(64.71%)下标记效率均≥90%。C组梯度场下pCASL采集的全脑灰质和几乎所有脑区的CBF明显高于A、B组(P均<0.05)。结论低G_(avg)及低G_(max)为5.0T全脑pCASL MRI最佳参数。Objective To explore the optimization for parameters of 5.0T pseudo continuous arterial spin labeling(pCASL)MRI of whole brain.Methods Nine healthy adults were prospectively enrolled,and single-delay pCASL scanning was performed based on a 5.0T MR scanner with 3 sets of labeling gradients:Group A,average gradient(G_(avg))=1 mT/m and the ratio of maximum gradient(G_(max))to G_(avg)(G_(ratio))=10,group B,G_(avg)=0.6 mT/m and G_(ratio)=10,group C,G_(avg)=0.3 mT/m and G_(ratio)=9.The labeling efficiency and cerebral blood flow(CBF)of 3 groups were compared to screen the best labeling gradient group.Results When the marked average blood flow velocity was 40 cm/s,the gradient field tolerance of group C was better than that of group A and B at the situation of reduced B1+and larger B0 offset frequency range.Under the gradient field of group C,the level of labeled artery B1 ranged from 54.19%to 75.36%,with an average of 64.71%.The labeling efficiencies of group C were all≥85%,and all≥90%at the average B1 level(64.71%).In the whole gray matter and almost all brain regions,CBF on pCASL under gradient field of group C was significantly higher than that of group A and B(all P<0.05).Conclusion Low G_(avg)and low G_(max)were the optimal parameters for 5.0T whole brain pCASL MRI.

关 键 词：脑 动脉自旋标记 磁共振成像 图像质量 前瞻性研究 

分 类 号：R742[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]