不同双能CT虚拟单能谱图像衍生影像组学特征的可重复性:实验研究  

Reproducibility of virtual monoenergetic CT image-derived radiomics features:Experimental study

作　　者：詹鹏超 刘星 李亚华[2,3] 吴锟鹏 李臻 吕培杰[1] 梁盼[1] 高剑波[1] ZHAN Pengchao;LIU Xing;LI Yahua;WU Kunpeng;LI Zhen;LYU Peijie;LIANG Pan;GAO Jianbo(Department of Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Department of Interventional Radiology,The First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;The Interventional Treatment and Clinical Research Center of Henan Province,Zhengzhou 450052,China)

机构地区：[1]郑州大学第一附属医院放射科,河南郑州450052 [2]郑州大学第一附属医院放射介入科,河南郑州450052 [3]河南省介入治疗与临床研究中心,河南郑州450052

出　　处：《中国医学影像技术》2024年第5期712-717,共6页Chinese Journal of Medical Imaging Technology

摘　　要：目的比较3种双能CT(DECT)系统在不同条件下所获VX2兔肝肿瘤模型虚拟单能谱图像(VMI)增强CT影像组学特征(RF)的可重复性及其与诊断效能的关系。方法将15只VX2兔肝肿瘤模型随机均分为3组,分别接受采用双源DECT(dsDECT)、快速kV切换DECT(rsDECT)或双层探测器DECT(dlDECT)于不同体积CT剂量指数(CTDIvol)(6、9及12 mGy)下腹部增强CT扫描,于40~140 keV内每间隔10 keV重建单能图像并提取RF;以组内相关系数(ICC)计算RF可重复性,以ICC≥0.80为可重复RF,比较不同CT仪配对之间及不同CTDIvol下可重复RF占比(R),以及相同CTDIvol下不同CT仪配对可重复RF数量(N)最大值相应重建能量水平;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),比较最佳可重复条件下可重复RF与其他RF的诊断效能,计算RF的ICC与相应AUC的Spearman相关系数。结果R rsDECT-dsDECT[6.45%,95%CI(2.36%,8.87%)]高于R dlDECT-dsDECT[0.72%,95%CI(0.15%,1.79%)]及R rsDECT-dlDECT[1.43%,95%CI(0.60%,4.06%)](校正P均<0.05);R_(9mGy)[3.70%,95%CI(1.31%,5.73%)]及R_(12mGy)[2.63%,95%CI(0.60%,6.69%)]高于R_(6mGy)[1.31%,95%CI(0.12%,1.55%)](校正P均<0.05)。6、9及12 mGy下,RF最佳可重复重建能量水平集中于50~70 keV,可重复RF的AUC均高于其他RF(校正P均<0.05),且RF可重复性与诊断效能相关(r s=0.102~0.516,P<0.05)。结论兔肝肿瘤模型VMI CT增强图像RF可重复性与DECT设备、CTDIvol水平及重建能量水平相关,可重复RF可能诊断效能更佳。Objective To observe the reproducibility of radiomics feature(RF)extracted from virtual monoenergetic image(VMI)of rabbit VX2 hepatoma models obtained with 3 different dual-energy CT(DECT)systems,and to explore relationship of reproducibility and diagnostic performance of RF.Methods Fifteen rabbits with VX2 hepatoma were randomly divided into 3 groups(each n=5).Contrast-enhanced abdominal CT scanning under volume CT dose index(CTDIvol)levels of 6,9 and 12 mGy were performed with dual-source DECT(dsDECT),rapid kV switching DECT(rsDECT)and dual-layer detector DECT(dlDECT),respectively.VMI were reconstructed at 10 keV increments from 40 to 140 keV.RF were extracted from VMI,the reproducibility was assessed using intra-class correlation coefficient(ICC),and those with ICC≥0.8 were considered as reproducible RF.The percentage of reproducible features(denoted by R)were compared among different scanner pairings and different CTDIvol levels.Within each CTDIvol group,the reconstruction energy levels yielding the maximum number(denoted by N)of common RF across different scanner pairings were identified.The receiver operating characteristic(ROC)curve was drawn,the area under the curve(AUC)was calculated,and the diagnostic efficacies of reproducible RF and other RF were compared under optimal reproducible conditions.Spearman correlation coefficient between ICC and the corresponding AUC of RF were calculated.Results R rsDECT-dsDECT(6.45%,95%CI[2.36%,8.87%])was higher than R dlDECT-dsDECT(0.72%,95%CI[0.15%,1.79%])and R rsDECT-dlDECT(1.43%,95%CI[0.60%,4.06%])(all adjusted P<0.05),R_(9mGy)(3.70%,95%CI[1.31%,5.73%])and R_(12mGy)(2.63%,95%CI[0.60%,6.69%])were higher than R_(6mGy)(1.31%,95%CI[0.12%,1.55%])(all adjusted P<0.05).The optimal reproducible reconstruction energy levels of RF under CTDIvol of 6,9 and 12 mGy concentrated at 50—70 keV.AUC of reproducible RFs were higher than of other RF(all adjusted P<0.05)and had certain correlation with the reproducibility(r s=0.102-0.516,P<0.05).Conclusion The reproducibility of RF e

关 键 词：肝肿瘤 实验性 兔 体层摄影术 X线计算机 影像组学 可重复性 结果 

分 类 号：R735.7[医药卫生—肿瘤] R73-3[医药卫生—临床医学] R445.3