静息态功能MRI观察脑小血管病患者额顶网络功能连接与认知功能的关系  

Resting-state functional MRI observation on relationship between functional connectivity of frontoparietal network and cognitive function in patients with cerebral small vessel disease

作　　者：雷婷 闫伟 唐思维 周慧玲 李海青 蒋玉星 贺曦 何淼 宋佳芮 周立静 李亚君 陈莉[1] LEI Ting;YAN Wei;TANG Siwei;ZHOU Huiling;LI Haiqing;JIANG Yuxing;HE Xi;HE Miao;SONG Jiarui;ZHOU Lijing;LI Yajun;CHEN Li(Department of Radiology,Affiliated Hospital of North Sichuan Medical College,Nanchong 637000,China;Department of Radiology,Peking Union Medical College Hospital,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100730,China;Department of Nuclear Medicine,Chongqing Liangjiang New District People's Hospital,Chongqing 388617,China;Department of Radiology,Ziyang People's Hospital,Ziyang 641300,China;Department of Radiology,Nanchong Third People's Hospital,Nanchong 637000,China)

机构地区：[1]川北医学院附属医院放射科,四川南充637000 [2]中国医学科学院,北京协和医学院北京协和医院放射科,北京100730 [3]重庆两江新区人民医院核医学科,重庆388617 [4]资阳市人民医院放射科,四川资阳641300 [5]南充市第三人民医院放射科,四川南充637000

出　　处：《中国医学影像技术》2024年第5期718-723,共6页Chinese Journal of Medical Imaging Technology

基　　金：南充市市校科技战略合作专项(20SXZRKX0011)、国家临床重点专科建设项目[川卫医政函(2023)87号]。

摘　　要：目的采用静息态功能MRI(rs-fMRI)观察脑小血管病(CSVD)患者额顶网络(FPN)功能连接(FC)与认知功能的关系。方法回顾性分析50例CSVD认知障碍患者(CI组)、65例CSVD认知正常患者(NC组)和60名健康对照者(HC组)头颅rs-fMRI及神经心理学测试结果;比较3组间及两两FPN FC存在差异的脑区;采用偏相关分析评估CI组与NC组间存在差异脑区FC值与认知评分的相关性。结果3组双侧扣带回、左侧额中回、右侧缘上回、右侧顶下小叶及右内侧额上回FC存在差异(FWE校正,P均<0.05)。相比NC组,CI组左侧扣带回FC减弱而右侧额下回及右内侧额上回FC增强(FWE校正,P均<0.05)。CSVD患者左侧扣带回FC减弱与画钟测验评分呈负相关(r=-0.159,P=0.049)。结论CSVD患者无论伴或不伴CI均存在广泛FPN FC改变;左侧扣带回与CSVD患者认知功能相关。Objective To observe the relationship between functional connectivity(FC)of frontoparietal network(FPN)and cognitive function in patients with cerebral small vessel disease(CSVD)using resting-state functional MRI(rs-fMRI).Methods rs-fMRI of 50 CSVD patients with cognitive impairment(CI group),65 CSVD patients with normal cognition(NC group)and 60 healthy controls(HC group),as well as outcomes of neuropsychological tests were retrospectively analyzed.Brain regions with different FC of FPN were compared among 3 groups and between each 2 groups.Partial correlation analysis was used to evaluate the correlations of FC of brain regions value being statistically different between CI and NC groups and cognitive scores.Results Significant differences of FC in bilateral cingulate gyrus,left middle frontal gyrus,right supramarginal gyrus,right inferior parietal lobule and right medial superior frontal gyrus were found among groups(FWE correction,all P<0.05).Compared with NC group,FC of left cingulate gyrus decreased,of right inferior frontal gyrus and right medial superior frontal gyrus increased in CI group(FWE correction,all P<0.05).The decreased FC value of left cingulate gyrus was negatively correlated with clock drawing test score in CSVD patients(r=-0.159,P=0.049).Conclusion CSVD patients with or without CI had extensive abnormal FC of FPN,and the left cingulate gyrus was associated with patient's cognitive function.

关 键 词：脑血管疾病 认知 磁共振成像 功能连接 

分 类 号：R743[医药卫生—神经病学与精神病学] R445.2[医药卫生—临床医学]