Ocular surface changes in moderate-to-severe acne vulgaris  

作　　者：Ci-Yi Pan Dong-Jie Sun Han-Ling Li Li Ma Min Zhang Song-Yuan Tang Hui Zhang 

机构地区：[1]Department of Ophthalmology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China [2]Department of Dermatology,First Affiliated Hospital of Kunming Medical University,Kunming 650032,Yunnan Province,China [3]Department of Stomatology,the First People’s Hospital of Yunnan Province,Kunming 650100,Yunnan Province,China [4]Institute of Health Studies,School of Public Health,Kunming Medical University,Kunming 650500,Yunnan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第6期1049-1057,共9页国际眼科杂志（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.81260145;No.82060175);Priority Union Foundation of Yunnan Provincial Science and Technology Department and Kunming Medical University(No.202001AY070001-050).

摘　　要：AIM:To investigate ocular surface disorders and tear function changes in patients with acne vulgaris and explore the potential relationship between acne vulgaris and dry eye.METHODS:This cross-sectional study included right eyes of 53 patients with acne vulgaris and 54 healthy controls.The participants completed the Ocular Surface Disease Index(OSDI)questionnaire.The following ocular surface-related parameters were measured:tear meniscus height(TMH),noninvasive tear breakup time(NIBUT),Schirmer I test(SIT),lipid layer thickness(LLT)score of the tear film,meibum score,meibomian gland orifice obstruction score,the ratio of meibomian gland loss,conjunctival hyperemia score,and corneal fluorescein staining(CFS)score.RESULTS:The stability of the tear film decreased in acne vulgaris patients.In the acne group,the TMH and NIBUT were lower,whereas the OSDI,meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss,and conjunctival hyperemia score were higher compared with controls(P<0.05).There were no significant differences in the CFS score,SIT,or LLT score between the groups(P>0.05).In two dry eye groups,the TMH,NIBUT,and LLT score were lower in the acne with dry eye(acne-DE)group,and the meibum score,meibomian gland orifice obstruction score,ratio of meibomian gland loss and conjunctival hyperemia score in the acne-DE group were higher(P<0.05).There were no significant differences between OSDI,SIT,and CFS score(P>0.05).CONCLUSION:Patients with moderate-to-severe acne vulgaris are more likely to experience dry eye than those without acne vulgaris.Reduced tear film stability and meibomian gland structure dysfunction are more pronounced in patients with moderate-to-severe acne and dry eye.

关 键 词：acne vulgaris meibomian gland dysfunction dry eye tear film 

分 类 号：R771.3[医药卫生—眼科]