Intravitreal conbercept injection with panretinal photocoagulation for high-risk proliferative diabetic retinopathy with vitreous hemorrhage  

作　　者：Yao Xu Qing Ye Wei Shen 

机构地区：[1]Department of Ophthalmology,the Fourth Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China [2]Department of Ophthalmology,Suzhou Kowloon Hospital,Shanghai Jiao Tong University School of Medcine,Suzhou 215000,Jiangsu Province,China [3]Department of Ophthalmology,the First Affiliated Hospital of Soochow University,Suzhou 215000,Jiangsu Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第6期1066-1072,共7页国际眼科杂志（英文版）

基　　金：Supported by Research Grants from the fund of Suzhou Kowloon Hospital(No.SZJL202106).

摘　　要：AIM:To assess the clinical efficacy and safety of combining panretinal photocoagulation(PRP)with intravitreal conbercept(IVC)injections for patients with high-risk proliferative diabetic retinopathy(HR-PDR)complicated by mild or moderate vitreous hemorrhage(VH),with or without diabetic macular edema(DME).METHODS:Patients diagnosed with VH with/without DME secondary to HR-PDR and received PRP combined with IVC injections were recruited in this retrospective study.Upon establishing the patient’s diagnosis,an initial IVC was performed,followed by prompt administration of PRP.In cases who significant bleeding persisted and impeded the laser operation,IVC was sustained before supplementing with PRP.Following the completion of PRP,patients were meticulously monitored for a minimum of six months.Laser therapy and IVC injections were judiciously adjusted based on fundus fluorescein angiography(FFA)results.Therapeutic effect and the incidence of adverse events were observed.RESULTS:Out of 42 patients(74 eyes),29 were male and 13 were female,with a mean age of 59.17±12.74y(33-84y).The diabetic history was between 1wk and 26y,and the interval between the onset of visual symptoms and diagnosis of HR-PDR was 1wk-1y.The affected eye received 2.59±1.87(1-10)IVC injections and underwent 5.5±1.02(4-8)sessions of PRP.Of these,68 eyes received PRP following 1 IVC injection,5 eyes after 2 IVC injections,and 1 eye after 3 IVC injections.Complete absorption of VH was observed in all 74 eyes 5-50wk after initial treatment,with resolution of DME in 51 eyes 3-48wk after initial treatment.A newly developed epiretinal membrane was noted in one eye.Visual acuity significantly improved in 25 eyes.No complications such as glaucoma,retinal detachment,or endophthalmitis were reported.CONCLUSION:The study suggests that the combination of PRP with IVC injections is an effective and safe modality for treating diabetic VH in patients with HR-PDR.

关 键 词：conbercept panretinal photocoagulation high-risk proliferative diabetic retinopathy vitreous hemorrhage 

分 类 号：R774.5[医药卫生—眼科]