The optimal atropine concentration for myopia control in Chinese children: a systematic review and network Metaanalysis  

作　　者：Xiao-Yan Wang Hong-Wei Deng Jian Yang Xue-Mei Zhu Feng-Ling Xiang Jing Tu Ming-Xue Huang Yun Wang Jin-Hua Gan Wei-Hua Yang 

机构地区：[1]School of Nursing,Southwest Medical University,Luzhou 646600,Sichuan Province,China [2]Shenzhen Eye Institute,Shenzhen Eye Hospital,Jinan University,Shenzhen 518040,Guangdong Province,China [3]Luzhou Traditional Chinese Medicine Hospital,Luzhou 646000,Sichuan Province,China [4]The Affiliated Hospital of Southwest Medical University,Luzhou 646099,Sichuan Province,China

出　　处：《International Journal of Ophthalmology(English edition)》2024年第6期1128-1137,共10页国际眼科杂志（英文版）

基　　金：Supported by the National Key R&D Plan“Intergovernmental International Scientific and Technological Innovation Cooperation”(No.2022YFE0132600);Shenzhen Fund for Guangdong Provincial High-level Clinical Key Specialties(No.SZGSP014);Sanming Project of Medicine in Shenzhen(No.SZSM202311012);Shenzhen Science and Technology Program(No.KCXFZ20211020163814021).

摘　　要：AIM:To figure out whether various atropine dosages may slow the progression of myopia in Chinese kids and teenagers and to determine the optimal atropine concentration for effectively slowing the progression of myopia.METHODS:A systematic search was conducted across the Cochrane Library,PubMed,Web of Science,EMBASE,CNKI,CBM,VIP,and Wanfang database,encompassing literature on slowing progression of myopia with varying atropine concentrations from database inception to January 17,2024.Data extraction and quality assessment were performed,and a network Meta-analysis was executed using Stata version 14.0 Software.Results were visually represented through graphs.RESULTS:Fourteen papers comprising 2475 cases were included;five different concentrations of atropine solution were used.The network Meta-analysis,along with the surface under the cumulative ranking curve(SUCRA),showed that 1%atropine(100%)>0.05%atropine(74.9%)>0.025%atropine(51.6%)>0.02%atropine(47.9%)>0.01%atropine(25.6%)>control in refraction change and 1%atropine(98.7%)>0.05%atropine(70.4%)>0.02%atropine(61.4%)>0.025%atropine(42%)>0.01%atropine(27.4%)>control in axial length(AL)change.CONCLUSION:In Chinese children and teenagers,the five various concentrations of atropine can reduce the progression of myopia.Although the network Meta-analysis showed that 1%atropine is the best one for controlling refraction and AL change,there is a high incidence of adverse effects with the use of 1%atropine.Therefore,we suggest that 0.05%atropine is optimal for Chinese children to slow myopia progression.

关 键 词：ATROPINE China children and adolescents MYOPIA network Meta-analysis 

分 类 号：R778.11[医药卫生—眼科]