新食品原料呲咯喹啉醌二钠盐固体饮料免疫功能作用的研究  

Immune Function Study of New Food Raw Material Pyrroloquinoline QuinoneDisodium Salt Solid Beverage

作　　者：吴巧娜[1] WU Qiaona(The Third Hospital of Shijiazhuang,Shijiazhuang 050000,China)

机构地区：[1]石家庄市第三医院,河北石家庄050000

出　　处：《现代食品》2024年第7期215-218,共4页Modern Food

摘　　要：目的:研究呲咯喹啉醌二钠盐固体饮料的免疫功能作用。方法:呲咯喹啉醌二钠盐低、中、高剂量组分别经口灌胃0.125 g·kg^(-1)、0.250 g·kg^(-1)、0.500 g·kg^(-1)受试物,对照组、模型组灌胃等量体积的生理盐水,连续30 d,考察各组小鼠免疫器官指数、碳廓清能力、巨噬细胞吞噬能力以及脾NK细胞活性。结果:与模型小鼠相比,经呲咯喹啉醌二钠盐灌胃30 d后,呲咯喹啉醌二钠盐各剂量组免疫器官指数上升,碳廓清能力、巨噬细胞吞噬能力均提升,脾NK细胞活性增强,其中呲咯喹啉醌二钠盐中、高剂量组变化明显(P<0.05,P<0.01),与模型组有显著差异。结论:呲咯喹啉醌二钠盐可通过调节非特异性免疫指标,达到调节免疫功能的作用。Objective:To study the immune function of pyrroloquinoline quinone disodium salt solid beverage.Method:The low,medium,and high dose groups of pyrroloquinoline quinone disodium salt were respectively orally administered with 0.125 g·kg^(-1),0.250 g·kg^(-1),and 0.500 g·kg^(-1)of the test substance,the control group and model group were orally administered with the same volume of physiological saline,all administered for 30 consecutive days.The immune organ index,carbon clearance ability,macrophage phagocytic ability,and spleen NK cell activity of each group of mice were examined.Result:Compared with the model group mice,after 30 d of oral administration of quinone disodium salt,the immune organ index of each quinone disodium salt dose group increased,carbon clearance ability and macrophage phagocytosis ability were improved,and spleen NK cell activity were enhanced.And the middle and high dose groups of quinone disodium salt showed significant changes(P<0.05,P<0.01),which were significantly different from the model group.Conclusion:Pyrroloquinoline quinone disodium salt can regulate immune function by regulating non-specific immune indicators.

关 键 词：呲咯喹啉醌二钠盐 固体饮料 免疫功能 

分 类 号：TS278[轻工技术与工程—农产品加工及贮藏工程]