卵巢-附件影像报告和数据系统分类联合血清学检查对卵巢-附件肿瘤的诊断价值  

Diagnostic value of ultrasound Ovarian-Adnexal Reporting and Data System classification combined with serum carbohydrate antigen 125 and human epididymis protein 4 for ovarian-adnexal masses

作　　者：冯景[1] 任永凤[1] 李健[1] 马利亚 李晓雪 FENG Jing;REN Yongfeng;LI Jian;MA Liya;LI Xiaoxue(Department of Ultrasound,the Affiliated Bozhou Hospital of Anhui Medical University(the People′s Hospital of Bozhou),Bozhou 236800,China)

机构地区：[1]安徽医科大学附属亳州医院(亳州市人民医院)超声科,亳州236800

出　　处：《中国临床保健杂志》2024年第2期273-276,共4页Chinese Journal of Clinical Healthcare

基　　金：安徽医科大学校基金资助项目(2022xkj231)。

摘　　要：目的探讨卵巢-附件影像报告和数据系统(O-RADS)分类联合血清糖类抗原125(CA125)及人附睾分泌蛋白4(HE4)对卵巢-附件肿瘤的诊断价值。方法回顾性分析安徽医科大学附属亳州医院(亳州市人民医院)收治并病理确诊的卵巢-附件肿瘤患者90例,以病理结果为金标准,分析超声O-RADS分类、血清CA125、HE4对卵巢-附件恶性肿瘤的检出率。运用受试者工作特征(ROC)曲线分析O-RADS分类、CA125、HE4及三者联合应用对卵巢-附件肿瘤的诊断效能。结果90例卵巢-附件肿瘤中,良性61例,恶性29例。O-RADS分类中2、3、4、5类对恶性肿瘤的检出率依次增高,与良性肿瘤比较,差异有统计学意义(P<0.001),血清CA125、HE4对恶性肿瘤的检出率分别为72.00%、70.37%,与良性肿瘤比较,差异有统计学意义(P均<0.001)。O-RADS分类、CA125、HE4及三者联合诊断卵巢-附件肿瘤的曲线下面积(AUC)分别为0.783、0.753、0.762、0.909,联合诊断AUC高于任一单独诊断技术(P均<0.05)。结论超声O-RADS分类联合血清CA125、HE4有助于提高卵巢-附件肿瘤的诊断效能。Objective To explore the diagnostic value of Ovarian-Adnexal Reporting and Data System(O-RADS)combined with serum carbohydrate antigen 125(CA125)and human epididymis protein 4(HE4)for ovarian-adnexal masses.Methods A total of 90 cases with ovarian-adnexal masses admitted to the Affiliated Bozhou Hospital of Anhui Medical University(the People′s Hospital of Bozhou)were retrospectively analyzed and pathologically diagnosed.Taking the pathological results as the gold standard,the detection rates of malignant ovarian-adnexal masses were analyzed by ultrasound O-RADS classification,serum CA125 and HE4.The diagnostic efficacy of O-RADS classification,serum CA125,HE4,and the combination of the three on the diagnosis of ovarian-adnexal masses was analyzed through ROC curve.Results Among 90 cases with ovarian-adnexal masses,61 were benign and 29 were malignant.The detection rates of malignant masses with O-RADS 2,3,4,5 classifications increased sequentially,with the statistically significant differences compared with benign masses(P<0.001).The detection rates of malignant masses in serum CA125 and HE4 were 72.00%and 70.37%,respectively,with the statistically significant differences compared with benign masses(all P<0.001).The area under the curve(AUC)of O-RADS classification,serum CA125,HE4,and the joint diagnosis of ovarian-adnexal masses was 0.783,0.753,0.762,and 0.909,respectively.The combination of the three was higher than any one of the individual diagnostic techniques(all P<0.05).Conclusions Ultrasound O-RADS classification combined with CA125,HE4 can improve the diagnostic efficiency of ovarian-adnexal masses.

关 键 词：卵巢肿瘤 诊断技术 妇产科 CA-125抗原 附睾分泌蛋白质类 超声检查 多普勒 彩色 

分 类 号：R737.31[医药卫生—肿瘤]