内向整流钾离子通道与视网膜疾病的关系  

The relationship between inwardly rectifying potassium channels and retinopathy

作　　者：李恋 杨旭 徐颖[3] 马红婕 Li Lian;Yang Xu;Xu Ying;Ma Hongjie(Aier Eye Hospital,Jinan University,Guangzhou 510071,China;Aier Eye Institute,Changsha 410000,China;Guangdong-Hongkong-Macao Institute of CNS Regeneration,Key Laboratory of CNS Regeneration(Ministry of Education),Jinan University,Guangzhou 510632,China)

机构地区：[1]暨南大学附属爱尔眼科医院,广州510071 [2]湖南省爱尔眼科研究所,长沙410000 [3]中枢神经再生教育部重点实验室(暨南大学),广州510632

出　　处：《国际眼科纵览》2024年第2期123-128,共6页International Review of Ophthalmology

基　　金：中枢神经再生教育部重点实验室(暨南大学)2021年度开放基金。

摘　　要：内向整流钾离子通道(inwardly rectifying K+channel,Kir通道)是钾离子通道家族中的一个亚类,在各种组织细胞中广泛分布,在维持机体环境稳态中具有重要作用.近期研究显示,其亦存在于视网膜色素上皮、视网膜神经元、胶质细胞及血管细胞中,具有维持视网膜渗透压稳态,抵抗神经毒性及氧化应激,参与视觉形成等重要作用.Kir通道参与了糖尿病性视网膜病变、遗传性KCNJ13视网膜病变、青光眼等多种视网膜疾病的发生发展.Inwardly rectifying potassium(Kir)channels,a subclass within the potassium channel family,are extensively distributed in a variety of tissue cells and play a vital role in maintaining bodily homeostasis.Recent research indicates their presence in the retinal pigment epithelium,neurons,glial cells,and vascular cells.These channels are instrumental in preserving retinal osmotic balance,combating neurotoxic and oxidative stress,and facilitating visual processing.Kir channels have been implicated in the progression of several retinal diseases,including diabetic retinopathy,hereditary KCNJ13-related retinal disorders,and glaucoma.

关 键 词：内向整流钾离子通道蛋白 视网膜疾病 

分 类 号：R774.1[医药卫生—眼科]