氯氮平联合利培酮对精神分裂症患者炎症因子水平及阳性与阴性症状量表评分的影响  

Effect of Clozapine combined with Risperidone on the levels of inflammatory factors and positive and negative syndrome scale scores in patients with schizophrenia

作　　者：袁爱平 杨舟 刘畅 YUAN Aiping;YANG Zhou;LIU Chang(Department of Psychiatry,Jiangxi Honorary Military Preferential Treatment Hospital,Jiangxi Province,Nanchang 330103,China)

机构地区：[1]江西省荣军优抚医院精神科,江西南昌330103

出　　处：《中国当代医药》2024年第15期36-39,共4页China Modern Medicine

基　　金：江西省卫生健康委科技计划项目(202311358)。

摘　　要：目的探讨氯氮平联合利培酮对精神分裂症(SZ)患者血清炎症因子水平及阳性与阴性症状量表(PANSS)评分的影响,以指导临床治疗措施拟定,促使SZ患者临床获益。方法选取2020年1月至2022年8月江西省荣军优抚医院接收的SZ患者80例作为研究对象,依据随机数字表法分为对照组(采用氯氮平治疗)和观察组(采用氯氮平联合利培酮治疗),每组各40例。比较两组的治疗效果、PANSS评分及相关血清炎症因子水平。结果观察组治疗总有效率高于对照组,差异有统计学意义(P<0.05)。观察组治疗后血清白细胞介素-13水平高于对照组,阴性症状、阳性症状、一般精神病评分及PANSS总分、血清肿瘤坏死因子-α水平低于对照组,差异有统计学意义(P<0.05)。两组患者药物不良反应总发生率的比较,差异无统计学意义(P>0.05)。结论利培酮、氯氮平联合治疗SZ效果显著,可有效降低PANSS评分,调节炎症因子水平。Objective To investigate the effects of Clozapine combined with Risperidone on serum inflammatory factor levels and positive and negative symptom scale(PANSS)scores in patients with schizophrenia(SZ),in order to guide the formulation of clinical treatment measures and promote clinical benefit in patients with SZ.Methods A total of 80 SZ patients admitted to Jiangxi Honorary Military Preferential Treatment Hospital from January 2020 to August 2022 were selected as the study objects,and they were divided into control group(treated with Clozapine)and observation group(treated with Clozapine combined with Risperidone)according to random number table method,with 40 cases in each group.The therapeutic effect,PANSS score and serum inflammatory factor levels were compared between the two groups.Results The total effective rate of observation group was higher than that of control group,and the difference was statistically significant(P<0.05).After treatment,the level of serum interleukin-13 in observation group was higher than that in control group,and the level of negative symptoms,positive symptoms,general psychiatric score,total score of PANSS and serum tumor necrosis factor-α were lower than that in control group,and the differences were statistically significant(P<0.05).There was no significant difference in the total incidence of adverse drug reactions between the two groups(P>0.05).Conclusion Risperidone combined with Clozapine has a significant effect on SZ,which can effectively reduce PANSS score and regulate the level of inflammatory factors.

关 键 词：精神分裂症 氯氮平 利培酮 炎症因子 

分 类 号：R749[医药卫生—神经病学与精神病学]