非动脉硬化性脑小血管病的治疗进展  

Advances in the treatment of non-arteriosclerotic cerebral small vessel disease

作　　者：温田思宇 崔梅 Wen Tiansiyu;Cui Mei(Department of Neurology,Huashan Hospital,Fudan University)

机构地区：[1]复旦大学附属华山医院神经内科,上海200040

出　　处：《重庆医科大学学报》2024年第5期515-521,共7页Journal of Chongqing Medical University

基　　金：科技创新2030重大资助项目(编号:2021ZD0201806);国家自然科学基金资助项目(编号:82271221);上海市医苑新星杰出青年医师计划资助项目(编号:20224Z0033)。

摘　　要：脑小血管病(cerebral small vessel disease,CSVD)是导致卒中和痴呆的常见原因。而除了常见的小动脉硬化性脑小血管病,非动脉硬化性脑小血管病的防治也不容忽视,目前这类疾病尚缺乏特异的治疗药物,且机制未明、异质性较强,但临床对症治疗方面已有部分证据,在深入挖掘机制的同时也探索出潜在疗法。现旨在对该领域治疗进展予以综述。Cerebral small vessel disease(CSVD)is a common cause of stroke and dementia.Besides the common type of arteriosclerotic CSVD,the prevention and treatment of non-arteriosclerotic arteriosclerotic CSVD should also be taken seriously.At present,there is still a lack of specific therapeutic drugs for such diseases due to unclear mechanisms and strong heterogeneity;however,some clinical evidence has been obtained for symptomatic treatment,and potential therapies are being explored alongside in-depth research on mechanisms.This article reviews the advances in treatment in this field.

关 键 词：脑小血管病 脑淀粉样血管病 伴皮质下梗死和白质脑病的常染色体显性遗传性脑动脉病 卒中 

分 类 号：R743.9[医药卫生—神经病学与精神病学]