多灶性/多中心性乳腺癌研究进展  

Research Progress of Multifocal/Multicentric Breast Cancer

作　　者：刘佳[1] 周星彤 孙强[1] LIU Jia;ZHOU Xingtong;SUN Qiang(Department of Breast Surgery,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医院乳腺外科,北京100730

出　　处：《协和医学杂志》2024年第3期632-641,共10页Medical Journal of Peking Union Medical College Hospital

基　　金：中央高水平医院临床科研专项(2022-PUMCH-B-038)。

摘　　要：影像学技术的进步使得越来越多的多灶性/多中心性乳腺癌(multifocal/multicentric breast cancer, MMBC)在早期被发现。传统观念认为,MMBC比单灶性乳腺癌(unifocal breast cancer, UBC)预后更差,应积极升级治疗手段。近年来,随着医疗水平的提升,MMBC患者的诊断、个体化治疗、接受保乳手术的安全性等焦点问题需重新被审视。本文将从MMBC流行病学特征、术前影像学评估、病理异质性与分子标志物、手术方式等多方面展开论述,以期加深临床认知。Advances in imaging techniques have allowed an increasing number of multifocal/multicentric breast cancers(MMBC)to be detected at an early stage.Traditionally,MMBC has been considered to have a worse prognosis than unifocal breast cancer(UBC)and should be treated with escalation therapy.With the ad-vancement of medical technology in recent years,the diagnosis,individualized treatment strategies,and the safety of breast-conserving surgery for MMBC need to be re-examined.This paper reviews the epidemiologic fea-tures,preoperative imaging assessment,pathological heterogeneity,molecular markers,and surgical approaches of MMBC,so as to deepen the knowledge of clinicians.

关 键 词：多灶性/多中心性乳腺癌 影像评估 保乳治疗 肿瘤整形术 

分 类 号：R737.9[医药卫生—肿瘤] R445[医药卫生—临床医学] R446.8