不忘初心,砥砺前行,做科研先锋——中国工程院院士吉训明教授  

Stay true to the original aspiration,forge ahead,and strive for excellence in the realm of science--Professor Ji Xunming,academician of Chinese Academy of Engineering

作　　者：顾超雄 李明 Gu Chaoxiong;Li Ming(Beijing Institute of Brain Disorders,Beijing 100069,China;Research Department Laboratory,Xuanwu Hospital,Capital Medical University,Beijing 100053,China)

机构地区：[1]北京脑重大疾病研究院,北京100069 [2]首都医科大学宣武医院科研处实验室,北京100053

出　　处：《首都医科大学学报》2024年第3期375-378,共4页Journal of Capital Medical University

摘　　要：吉训明教授是中国工程院院士,研究领域为神经病学。在动脉和静脉性卒中的发病机制、脑血流重建和神经保护等方面取得较为系统的原创性成果,并推进其临床转化与应用。①提出“低氧组织适应”学说,发现并证实低氧适应脑保护作用,阐明其抗缺血缺氧损伤机制;②建立“肢体远隔缺血适应”新方法,证实其防治缺血性脑卒中的作用,揭示多靶点协同调控的“干预外周、保护中枢”机制,奠定临床转化基础;③研究开发双上肢远隔缺血适应专用设备,获医疗器械注册证和生产许可证,实现临床转化;④创建双上肢远隔缺血适应防治缺血性脑卒中临床应用新策略,制定国际指南。这些科研突破对认识动静脉性卒中的损伤机制、系统救治及其神经保护策略均有重要意义,多项研究成果被写入国际学术专著、国际指南和国际经典教科书。Professor Ji Xunming is an academician of Chinese Academy of Engineering in the field of neurology.He has made systematic and original achievements in the pathogenesis of arterio-venous stroke,cerebral blood flow reconstruction,and neuroprotection,in addition,he has also advanced their clinical translation and application.It mainly includes:①Proposing the“hypoxic tissue adaptation”theory,discovering and confirming the neuroprotective effects of hypoxic adaptation,and further elucidating its mechanisms against ischemic and hypoxic injuries.②Establishing a new method of“remote ischemic conditioning of the limbs”,verifying its role in preventing and treating ischemic stroke,and revealing the multi-target coordinated regulation mechanism of“intervening peripherally to protect centrally”,laying the foundation for clinical translation.③Developing specialized equipment for remote ischemic conditioning of the upper limbs,obtaining medical device registration and production licenses,and achieving clinical translation.④Creating a new strategy for the clinical application of remote ischemic conditioning of the upper limbs in the prevention and treatment of ischemic stroke,and formulating international guidelines.These scientific breakthroughs are of great significance for understanding the mechanisms of injury in arterio-venous stroke,systematic treatment,and neuroprotective strategies,and his many research findings are included in international academic monographs,guidelines,and classic textbooks.

关 键 词：低氧组织适应 远隔缺血适应 神经保护 缺血性脑卒中 动静脉性卒中 

分 类 号：R743[医药卫生—神经病学与精神病学]