多胺在肿瘤发生发展中的作用及其干预研究进展  

Advances of polyamines in tumorigenesis,development and intervention research

作　　者：陈美宇 徐静 张大猛 杜沛龙 朱馨婷 韩冷 郭澄[1] 杨全军[1] CHEN Mei-yu;XU Jing;ZHANG Da-meng;DU Pei-long;ZHU Xin-ting;HAN Leng;GUO Cheng;YANG Quan-jun

机构地区：[1]上海交通大学医学院附属第六人民医院,200233 [2]上海健康医学院药学院,201318

出　　处：《中国医药生物技术》2024年第3期260-265,共6页Chinese Medicinal Biotechnology

基　　金：国家自然科学基金(82272925);上海市浦江人才计划(21PJ1411900);中国药学会医院药学专业委员会医院药学拔尖人才专项(CPA-Z05-ZC-2022-03)。

摘　　要：多胺在肿瘤发生发展、靶向治疗和免疫治疗方面发挥着重要的作用。多胺包括腐胺、精胺和亚精胺等,临床研究和实验结果显示肿瘤存在多种形式的多胺代谢异常,且多胺代谢异常的研究对于肿瘤靶向治疗、免疫治疗生化标志物研究具有重要价值。随着对多胺在肿瘤发生发展和肿瘤治疗中作用的认识不断加深,人们对以多胺代谢为靶点的抗肿瘤干预策略的兴趣日益加深。本文综述多胺及其代谢与不同类型肿瘤进展的关系,旨在总结多胺代谢调控的药物靶点和临床防治药物开发策略。Polyamines play an important role in tumour development,targeted therapy and immunotherapy.Polyamines include putrescine,spermine,spermidine and so on.The results from clinical and experimental studies have shown that polyamine metabolic abnormalities have been found in multiple forms during tumourigenesis and development.The study of the abnormalities is of great value for the study of biochemical markers in tumour-targeted therapy and immunotherapy.With the increasing understanding of the role of polyamines in tumour development and therapy,there is a growing interest in anti-tumour intervention strategies targeting polyamine metabolism.This review not only focuses on the relationship between polyamine/polyamine-metabolism and the progression of different type of tumour,but also aims to summarize the drug targets and development strategies for clinical prevention and treatment for the regulation of polyamine metabolism.

关 键 词：多胺 腐胺 精胺 亚精胺 肿瘤 生化标志物 靶向治疗 

分 类 号：R73[医药卫生—肿瘤]