阻塞性睡眠呼吸暂停低通气综合征合并重症哮喘的研究现状和挑战  

Obstructive Sleep Apnea-hypopnea Syndrome and Severe Asthma:Advances and Challenges

作　　者：朱亚敏 杜莉 王焕辉 王配配 ZHU Yaming;DU Li;WANG Huanhui;WANG Peipei(General Medicine Department,Sanya Central Hospital(Hainan Third People's Hospital),Sanya 572000,China;Sleep Medicine Department,Sanya Central Hospital(Hainan Third People's Hospital),Sanya 572000,China;Hainan Medical University,Haikou 570100,China)

机构地区：[1]三亚中心医院(海南省第三人民医院)全科医学科,海南省三亚市572000 [2]三亚中心医院(海南省第三人民医院)睡眠医学科,海南省三亚市572000 [3]海南医学院,海南省海口市570100

出　　处：《中国全科医学》2024年第25期3192-3196,共5页Chinese General Practice

基　　金：国家自然科学基金资助项目(82160025);海南省科技专项资助(ZDYF2020127)。

摘　　要：阻塞性睡眠呼吸暂停低通气综合征(OSAHS)和哮喘是两种发病率较高的慢性呼吸系统疾病。近年来研究显示,OSAHS不仅与哮喘存在多种共同的危险因素,两者的共病率也相对较高,并使彼此的疾病进程变得更加复杂,增加了临床诊疗的难度。本综述旨在从流行病学和病理生理学的角度对OSAHS合并哮喘(尤其是重症哮喘)的研究进展与面临的挑战进行总结与探讨。Obstructive Sleep Apnea-Hypopnea Syndrome(OSAHS)and asthma are two prevalent chronic respiratory diseases.Recent research has revealed that OSAHS not only shares several common risk factors with asthma but also exhibits a high comorbidity rate with it.This mutual interaction complicates the course of both diseases and increases complexity to clinical diagnosis and treatment.This review aims to provide a comprehensive summary and analysis,from an epidemiological and pathophysiological perspective,of the research progress and challenges concerning the OSAHS comorbided with asthma,particularly in severe asthma.

关 键 词：睡眠呼吸暂停 阻塞性 哮喘 共病现象 危险因素 综述 

分 类 号：R749.79[医药卫生—神经病学与精神病学]