运动干预对乳腺癌新辅助化疗患者心肺耐力影响的Meta分析  

Meta Analysis on the Effects of Exercise Intervention on Cardiopulmonary Endurance of Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

作　　者：刘雅清 黄招阳[2] 杨素娟 LIU Yaqing;HUANG Zhaoyang;YANG Sujuan(Fujian University of Traditional Chinese Medicine,Fuzhou 350122,China;Clinical Oncology School of Fujian Medical University,Fujian Cancer Hospital,Fuzhou 350014,China)

机构地区：[1]福建中医药大学,福州350122 [2]福建医科大学肿瘤临床医学院,福建省肿瘤医院,福州350014

出　　处：《中国医药指南》2024年第16期1-5,共5页Guide of China Medicine

基　　金：福建省卫生健康委医学创新课题(2022CXA030)。

摘　　要：目的 评价运动干预对乳腺癌新辅助化疗患者的影响。方法 系统检索PubMed、Web of Science、中国知网等数据库中关于乳腺癌新辅助化疗患者在常规护理的基础上联合运动训练的临床干预试验,检索时间为建库至2023年12月。根据纳入与排除标准筛选文献、提取资料。对文献进行质量评估,采用RevMan 5.4软件进行Meta分析。结果 最终纳入8篇文献,文献质量中等,共203例患者,其中对照组99例,干预组104例。结果显示运动干预能有效提高乳腺癌新辅助化疗患者心肺耐力,干预组峰值摄氧量(MD 3.97,95%CI 1.59~6.34,P=0.001)、最大摄氧量(MD 3.67,95%CI 0.59~6.76,P=0.02)、6 min步行试验(MD 89.18,95%CI 66.50~111.86,P <0.00001)均优于对照组;干预组BMI改善情况优于对照组(MD-4.00,95%CI-5.53~-2.47,P <0.00001);两组生命质量(MD 5.95,95%CI-4.39~16.30,P=0.26)和癌因性疲乏(MD-1.64,95%CI-7.75~4.46,P=0.60)差异无统计学意义。结论 运动干预能有效提高乳腺癌新辅助化疗患者的心肺耐力和改善BMI。Objective To evaluate the effect of exercise intervention on breast cancer patients with neoadjuvant chemotherapy.Methods This study visited PubMed,Web of Science,CNKI and gathered reports published until December 2023 on clinical intervention trials,whereby exercise intervention were prescribed on top of the routine nursing care to breast cancer patients treated with neoadjuvant chemotherapy.Literature was screened and data were extracted according to inclusion and exclusion criteria.To evaluate the quality of literature,Meta-analysis was performed using RevMan 5.4 software.Results A total of 203 cases from eight moderate-quality papers were included and divided into the control group(n=99) and the intervention group(n=104).The results showed that exercise intervention was effective in improving cardiorespiratory endurance in patients undergoing neoadjuvant chemotherapy for breast cancer,with peak oxygen uptake(MD 3.97,95% CI 1.59~6.34,P=0.001),maximal oxygen uptake(MD 3.67,95% CI 0.59~6.76,P=0.02),6 min walk test(MD 89.18,95% CI 66.50~111.86,P<0.00001) were better than those of the control group0;the improvement of BMI in the intervention group was better than that of the control group(MD-4.00,95% CI-5.53~-2.47,P<0.00001);quality of life in both groups(MD 5.95,95% CI-4.39~16.30,P=0.26) and cancer-caused fatigue(MD-1.64,95% CI-7.75~4.46,P=0.60) differences were not statistically significant.Conclusions Exercise intervention can effectively improve the cardiorespiratory endurance and BMI of breast cancer patients with neoadjuvant chemotherapy.

关 键 词：乳腺癌 新辅助化疗 运动训练 心肺耐力 META分析 

分 类 号：R737.9[医药卫生—肿瘤]