血清人附睾蛋白4、糖类抗原15-3、ROMA指数对上皮性卵巢癌复发的预测价值  

Predictive value of serum human epididymis protein 4,carbohydrate antigen 15-3 and ROMA index for recurrence of epithelial ovarian cancer

作　　者：田发 魏冰 薛明慧 朱珂宇 杨海鸥[1] TIAN Fa;WEI Bing;XUE Minghui;ZHU Keyu;YANG Haiou(Department of Clinical Laboratory/Shanghai Key Laboratory of Embryological Diseases,International Peace Maternity and Child Health Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院检验科/上海市胚胎源性疾病重点实验室,上海200030

出　　处：《检验医学与临床》2024年第11期1606-1610,1616,共6页Laboratory Medicine and Clinic

基　　金：2022年度上海交通大学“交大之星”计划医工交叉研究基金项目-青年项目(YG2022QN114)。

摘　　要：目的分析血清人附睾蛋白4(HE4)、糖类抗原15-3(CA15-3)联合卵巢癌风险评估模型(ROMA)指数对上皮性卵巢癌(EOC)复发的预测价值。方法选取2018年1月1日至2022年1月1日于该院妇产科就诊的135例EOC患者作为研究对象。分析HE4、CA15-3水平及ROMA指数在不同肿瘤类型、淋巴结转移情况、国际妇产联盟分期(FIGO)分期及复发情况的EOC患者上的差异。绘制受试者工作特征(ROC)曲线分析HE4、CA15-3及ROMA指数单独及3项指标联合检测对EOC患者3年复发的预测价值。结果浆液性囊腺癌患者的ROMA指数、HE4、CA15-3水平均高于黏液性囊腺癌、子宫内膜样腺癌、交界性癌、透明细胞癌、其他类型癌患者,差异均有统计学意义(P<0.05);子宫内膜样腺癌患者HE4水平明显高于黏液性囊腺癌、交界性癌、透明细胞癌及其他类型癌患者,且透明细胞癌患者HE4水平明显高于黏液性囊腺癌、交界性癌及其他类型癌患者,差异均有统计学意义(P<0.05);透明细胞癌患者CA15-3水平明显高于黏液性囊腺癌、子宫内膜样腺癌、交界性癌及其他类型癌患者,且子宫内膜样腺癌患者CA15-3水平明显高于黏液性囊腺癌、交界性癌及其他类型癌患者,差异均有统计学意义(P<0.05);子宫内膜样腺癌患者ROMA指数明显高于黏液性囊腺癌、交界性癌、透明细胞癌及其他类型癌患者,且透明细胞癌患者ROMA指数明显高于黏液性囊腺癌、交界性癌及其他类型癌患者,差异均有统计学意义(P<0.05)。FIGO分期Ⅲ期患者ROMA指数、HE4、CA15-3水平均明显高于FIGO分期Ⅰ期及FIGO分期Ⅱ期患者,且FIGOⅡ期患者明显高于FIGOⅠ期患者,差异均有统计学意义(P<0.05)。有淋巴结转移的患者ROMA指数、HE4、CA15-3水平均明显高于无淋巴结转移的患者,差异均有统计学意义(P<0.05)。在规定的时间内,共计有28例患者出现复发,107例患者未出现复发。EOC复发患者的ROMA指数、HE4、CA15-Objective To analyze the predictive value of serum human epididymis protein 4(HE4),carbohydrate antigen 15-3(CA15-3)combined with ovarian cancer risk assessment model(ROMA)index in the recurrence of epithelial ovarian cancer(EOC).Methods A total of 135 EOC patients who were treated in the Department of Obstetrics and Gynecology of the hospital from January 2018 to January 2022 were selected as the research objects.The differences of HE4,CA15-3 levels and ROMA index in EOC patients with different tumor types,lymph node metastasis,international federation of gynecology and obste trics staging(FIGO)stage and recurrence were analyzed.Receiver operating characteristic(ROC)curve was drawn to analyze the predictive value of HE4,CA15-3 and ROMA index alone and combined detection of the 3 indicators for 3-year recurrence of EOC patients.Results The ROMA index,HE4 and CA15-3 levels in patients with serous cystadenocarcinoma were significantly higher than those in patients with mucinous cystadenocarcinoma,endometrioid adenocarcinoma,borderline cancer,clear cell carcinoma and other types of cancer,and the differences were statistically significant(P<0.05).The level of HE4 in patients with endometrioid adenocarcinoma was significantly higher than that in patients with mucinous cystadenocarcinoma,borderline cancer,clear cell carcinoma and other types of cancer,and the level of HE4 in patients with clear cell carcinoma was significantly higher than that in patients with mucinous cystadenocarcinoma,borderline cancer and other types of cancer,with statistically significant differences(P<0.05).The level of CA15-3 in patients with clear cell carcinoma was significantly higher than that in patients with mucinous cystadenocarcinoma,endometrioid adenocarcinoma,borderline cancer and other types of cancer,and the level of CA15-3 in patients with endometrioid adenocarcinoma was significantly higher than that in patients with mucinous cystadenocarcinoma,borderline cancer and other types of cancer,with statistically significant differences

关 键 词：上皮性卵巢癌 血清人附睾蛋白-4 糖类抗原125 糖类抗原15-3 卵巢癌风险评估模型指数 

分 类 号：R737.31[医药卫生—肿瘤] R44.61[医药卫生—临床医学]